Results 101 to 110 of about 252,506 (348)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

open access: yesAdvanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel   +16 more
wiley   +1 more source

Growth and Behavior of North American Microbes on Phragmites australis Leaves

open access: yesMicroorganisms, 2020
Phragmites australis subsp. australis is a cosmopolitan wetland grass that is invasive in many regions of the world, including North America, where it co-occurs with the closely related Phragmites australis subsp. americanus.
Aaron E. DeVries   +2 more
doaj   +1 more source

Topological Tracking of Connected Components in Image Sequences

open access: yes, 2018
Persistent homology provides information about the lifetime of homology classes along a filtration of cell complexes. Persistence barcode is a graphical representation of such information.
Gonzalez-Diaz, Rocio   +2 more
core   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang   +12 more
wiley   +1 more source

Penggunaan Teknologi Augmented Reality Berbasis Barcode sebagai Sarana Penyampaian Informasi Spesifikasi dan Harga Barang yang Interaktif Berbasis Android, Studi Kasus pada Toko Elektronik ABC Surabaya

open access: yesJurnal Teknik ITS, 2013
Augmented reality adalah suatu teknologi yang memungkinkan orang untuk memvisualisasikan dunia maya sebagai bagian dari dunia nyata yang ada di sekitar secara efektif sehingga membuat dunia nyata seakan-akan dapat terhubung dengan dunia maya dan dapat ...
Febrian Wahyutama   +2 more
doaj  

A statistical approach to persistent homology

open access: yes, 2007
Assume that a finite set of points is randomly sampled from a subspace of a metric space. Recent advances in computational topology have provided several approaches to recovering the geometric and topological properties of the underlying space.
Om Samples   +6 more
core   +4 more sources

Unsynchronized 4D Barcodes [PDF]

open access: yes, 2007
We present a novel technique for optical data transfer between public displays and mobile devices based on unsynchronized 4D barcodes. We assume that no direct (electromagnetic or other) connection between the devices can exist. Time-multiplexed, 2D color barcodes are displayed on screens and recorded with camera equipped mobile phones.
Langlotz, Tobias   +1 more
openaire   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

open access: yesAdvanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su   +10 more
wiley   +1 more source

Conformable Microelectrode Arrays Integrated with a Scoop‐Shaped Slide‐Well for Dynamic Electrophysiological Profiling of Patient‐Derived Cardiac Organoids

open access: yesAdvanced Science, EarlyView.
A flexible, ultrathin multi‐channel microelectrode array (MEA) conformally integrated onto a curved slide‐well enables stable electrical interfacing with 3D cardiac organoids. The geometry‐guided self‐alignment allows simultaneous recording of extracellular field potentials and contractile motion from irregular, beating tissues.
Ye Seul Kim   +12 more
wiley   +1 more source

Fibers and fabrics for chemical and biological sensing [PDF]

open access: yes, 2012
Wearable sensors can be used to monitor many interesting parameters about the wearer’s physiology and environment, with important applications in personal health and well-being, sports performance and personal safety.
Benito-Lopez, Fernando   +4 more
core  

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