Results 51 to 60 of about 252,506 (348)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

SNP analysis of nasopharyngeal carcinoma (NPC) associated genetic loci in LMP1 signalling pathway genes in tribal populations from North-Eastern India using computational methods

Egyptian Journal of Medical Human Genetics
Background Nasopharyngeal carcinoma (NPC), a rare head and neck cancer, has distinct racial and geographic characteristics. It is considered rare in India, with the exception of a few endemic locations in the Northeast (NE), namely Manipur, Mizoram, and ...
Sudip Kumar Ghosh, Raima Das Kundu, Sankar Kumar Ghosh   +2 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Marine nematode taxonomy in the DNA age: the present and future of molecular tools to access their biodiversity [PDF]

, 2010
Molecular taxonomy is one of the most promising yet challenging fields of biology. Molecular markers such as nuclear and mitochondrial genes are being used in a variety of studies surveying marine nematode taxa.
da Silva, Maria Cristina, de Ley, Paul, Decraemer, Wilfrida, dos santos correla, Maria Tereza, Esteves, Andre Morgado, Gomes Fonseca Genevois, Veronica, Rieger, Tania Tassinari, Rodriguez Da Silva, Neyvan Renato   +7 more
core   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hidden Diversity Hampers Conservation Efforts in a Highly Impacted Neotropical River System

Frontiers in Genetics, 2018
Neotropical Rivers host a highly diverse ichthyofauna, but taxonomic uncertainty prevents appropriate conservation measures. The Doce River Basin (DRB), lying within two Brazilian threatened hotspots (Atlantic Forest and Brazilian Savanna) in south-east ...
Naiara G. Sales, Stefano Mariani, Gilberto N. Salvador, Tiago C. Pessali, Daniel C. Carvalho   +4 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

DNA barcoding and eDNA barcoding in diatoms

, 2014
Die lichtmikroskopische Bewertung der Diversität von Diatomeen ist eine erfolgreich praktizierte Methode zur Gewässergüteanalyse, die z.B. auch in der Wasserrahmenrichtlinie der Europäischen Union umgesetzt wird. Die vorliegende Arbeit stellt environmental DNA (eDNA) Barcoding als Alternative zur üblichen Untersuchung von Diatomeengesellschaften mit ...
Zimmermann, Jonas, Justus Liebig University Giessen   +1 more
openaire   +3 more sources

Pair-barcode high-throughput sequencing for large-scale multiplexed sample analysis

BMC Genomics, 2012
Background The multiplexing becomes the major limitation of the next-generation sequencing (NGS) in application to low complexity samples. Physical space segregation allows limited multiplexing, while the existing barcode approach only permits ...
Tu Jing, Ge Qinyu, Wang Shengqin, Wang Lei, Sun Beili, Yang Qi, Bai Yunfei, Lu Zuhong   +7 more
doaj   +1 more source

Bumblebees of the hypnorum-complex world-wide including two new near-cryptic species (Hymenoptera: Apidae)

European Journal of Taxonomy, 2022
The hypnorum-complex of bumblebees (in the genus Bombus Latreille, 1802) has been interpreted as consisting of a single widespread Old-World species, Bombus hypnorum (Linnaeus, 1758) s.
Paul H. Williams, Phurpa Dorji, Zongxin Ren, Zhenghua Xie, Michael Orr   +4 more
doaj   +1 more source