A modular lentiviral system for multiplexed gene perturbation and functional analysis suggests interdependence of hormone receptors in breast cancer growth in vivo. [PDF]
Alam S +10 more
europepmc +1 more source
Single‐cell and spatial transcriptomics implicate senescent B cells and macrophage migration inhibitory factor (MIF) signaling in aging and osteoarthritic joints. An injectable hydrogel combining quercetin with siRNA targeting MIF attenuates cartilage degeneration in a mouse model of osteoarthritis.
Weida Li +11 more
wiley +1 more source
Correction: Leaf beetle diversity on a Southeast Asian continental island: Taxonomy, DNA barcoding, and preliminary evolutionary insights from Cat Ba Island, Vietnam. [PDF]
Nguyen DT, Ho LT.
europepmc +1 more source
Bacteria residing within tumor cells contribute to breast cancer progression, but few therapies target their elimination. FeSe2 nanosheets coated with cancer cell membranes accumulate in tumors and generate reactive oxygen species under ultrasound, killing tumor cells and their harbored bacteria at the same time.
Xiaojing Leng +8 more
wiley +1 more source
Integrated ITS2 DNA Barcoding and LC-QTOF/MS Metabolomics for Authentication of Ngueak Pla Mo (<i>Acanthus</i> spp.) and Differentiation of Pharmacopoeial Species from <i>A. montanus</i> L. [PDF]
Chaichit S +3 more
europepmc +1 more source
A first single‐cell atlas of human orchitis reveals coordinated germ‐cell loss, somatic niche dysfunction, and immune‐metabolic remodeling. Aberrant SREBP2 activation in testicular somatic cells emerges as a central pathogenic node, while Fatostatin‐mediated inhibition of the SREBP pathway improves spermatogenesis, fibrosis, and lipid accumulation in a
Yanlin Tang +16 more
wiley +1 more source
18F‐FGln PET/CT imaging serves as a marker of Gln uptake in hepatocellular carcinoma. Tumors with high Gln uptake drive Treg‐mediated immunosuppression and immune evasion during antitumor immunotherapy. Conversely, tumors with low Gln uptake maintain sufficient Gln in the TME, suppressing Tregs and enabling cytotoxic T cells to inhibit tumor growth ...
Yi Liu +8 more
wiley +1 more source
DNA barcoding to delineate species boundaries and assess genetic divergence in halophytes of the United Arab Emirates. [PDF]
Jamdade R +5 more
europepmc +1 more source
A Large Scale Multi‐Modal Workflow for Battery Characterization: From Concept to Implementation
Isolated characterization techniques produce independent datasets and single‐property insights. However, progressively more holistic interpretations of battery‐material behavior is needed in the future. Here we demonstrate a coordinated multimodal workflow enabling the correlation of heterogeneous datasets and the construction of multidimensional ...
François Cadiou +34 more
wiley +1 more source

