Results 51 to 60 of about 10,296 (233)
ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function
FEBS Open Bio, EarlyView.Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley +5 more
wiley +1 more source
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Effect of barefoot walking on foot arch structure in Tribal children
Asian Journal of Medical Sciences, 2016 Background: The anatomy of human foot owes its adaptation to bipedal locomotion. Support and propulsion are the two main activities of foot which are possible due to segmental nature of foot.
Shanmukha Varalakshmi Vangara
doaj +1 more source
The Biomechanical Characteristics of the Cerebral Palsy Children When Walking with Bare-Foot
Applied Physics, 2015 目的：研究脑瘫儿童步行过程下肢生物力学特征。方法：中岳阳医院步态分析实验室课题组自2013到2015年采集33名脑瘫患儿三维步态数据，其粗大运动功能分级为Ⅰ~Ⅲ级，有自主行动能力，符合试验要求，能够完成试验。课题组将病例按照年龄分组(3~5岁组，6~7岁组)并与近十年本步态分析实验室采集的相同年龄段中国正常儿童三维步态数据做对照，分别运用两独立样本T检验，得到下肢运动学及动力学数据，并分析脑瘫儿童步行过程中下肢生物力学特征。结果：与正常儿童相比，同年龄脑瘫患儿双侧步长、步速、单支撑相明显减小(p < 0.05)；双侧步宽、双支撑相明显增大(p < 0.05)。各关节运动学方面：脑瘫患儿髋关节摆动相屈曲角度明显增大(p < 0.05)；左侧踝关节摆动相跖屈角度明显偏低(p < 0.05 ...
openaire +1 more source
Cell surface CD11c as a neutrophil aging marker molecule
FEBS Open Bio, EarlyView.Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki +5 more
wiley +1 more source
Moment acting at the metatarsophalangeal joints during normal barefoot level walking
Gait & Posture, 1993 Abstract The functional role of the moments acting at the metatarsophalangeal joints of the foot during bipedal human locomotion is discussed in relation to the time sequence of the foot contact events of the both feet and to the controllability of the angular momentum of the whole body.
Shinji MIYAZAKI, Sumiko YAMAMOTO
openaire +2 more sources
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
SPG4 and Dementia: Expanding the Clinical Spectrum
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza +19 more
wiley +1 more source
Nigerian Journal of Medicine, 2018 INTRODUCTION: Diabetic foot ulcer is a complication of diabetes mellitus of great public health importance. It has the potential of leading to the dreaded sequelae of lower extremity amputation.
M Enamino +3 more
doaj +1 more source
The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp +4 more
wiley +1 more source