Results 61 to 70 of about 10,004 (233)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Biomechanical Characteristics of the Cerebral Palsy Children When Walking with Bare-Foot
Applied Physics, 2015 目的：研究脑瘫儿童步行过程下肢生物力学特征。方法：中岳阳医院步态分析实验室课题组自2013到2015年采集33名脑瘫患儿三维步态数据，其粗大运动功能分级为Ⅰ~Ⅲ级，有自主行动能力，符合试验要求，能够完成试验。课题组将病例按照年龄分组(3~5岁组，6~7岁组)并与近十年本步态分析实验室采集的相同年龄段中国正常儿童三维步态数据做对照，分别运用两独立样本T检验，得到下肢运动学及动力学数据，并分析脑瘫儿童步行过程中下肢生物力学特征。结果：与正常儿童相比，同年龄脑瘫患儿双侧步长、步速、单支撑相明显减小(p < 0.05)；双侧步宽、双支撑相明显增大(p < 0.05)。各关节运动学方面：脑瘫患儿髋关节摆动相屈曲角度明显增大(p < 0.05)；左侧踝关节摆动相跖屈角度明显偏低(p < 0.05 ...
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Nigerian Journal of Medicine, 2018 INTRODUCTION: Diabetic foot ulcer is a complication of diabetes mellitus of great public health importance. It has the potential of leading to the dreaded sequelae of lower extremity amputation.
M Enamino +3 more
doaj +1 more source
Kinematic characteristics of barefoot sprinting in habitually shod children [PDF]
PeerJ, 2018 Background Anecdotally, a wide variety of benefits of barefoot running have been advocated by numerous individuals. The influence of the alterations in the properties of the shoe on the running movement has been demonstrated in adults at submaximal ...
Jun Mizushima +6 more
doaj +2 more sources
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
Moment acting at the metatarsophalangeal joints during normal barefoot level walking
Gait & Posture, 1993 Abstract The functional role of the moments acting at the metatarsophalangeal joints of the foot during bipedal human locomotion is discussed in relation to the time sequence of the foot contact events of the both feet and to the controllability of the angular momentum of the whole body.
Shinji MIYAZAKI, Sumiko YAMAMOTO
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FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Annals of Tropical Research, 2017 Seedling management is very important in leafy vegetable with short period of growing as it covers almost half of the production period. Pechay is considered a high value and a highly demanded leaf vegetable in the Philippines.
Zenaida C. Gonzaga +15 more
doaj +1 more source