Results 91 to 100 of about 138,331 (318)

The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial [PDF]

, 2016
Background: Despite improving evidence-based practice following clinical guidelines to optimise drug therapy, Type 2 diabetes (T2DM) still exerts a devastating toll from vascular complications and premature death.
Adamson, Ashley, Barnes, Alison, Brosnahan, Naomi, Ford, Ian, Hollingsworth, Kieren G., Kean, Sharon, Lean, Mike E.J., Leslie, Wilma S., Mathers, John C., McCombie, Louise, McIlvenna, Yvonne, Peters, Carl, Rehackova, Lucia, Rodrigues, Angela, Ross, Hazel, Sattar, Naveed, Sniehotta, Falko F., Taylor, Roy, Thom, George, Zhyzhneuskaya, Sviatlana   +19 more
core   +3 more sources

Exploring the Role of TAS2Rs in Obesity: Insights From Human and Rat Models

Obesity, EarlyView.
ABSTRACT Objective Obesity is a chronic disease with various causes and diverse treatments, including dietary restriction and bariatric surgery. Bitter taste receptors (TAS2Rs), found in the oral cavity and gastrointestinal tract (GIT), are implicated in digestive and metabolic regulation, but their role in obesity remains unclear.
Maria Descamps‐Solà, Florijan Jalševac, Adrià Vilalta, Margalida Fontcuberta, Harry Park, Carmen Aguilar, Teresa Auguet, Raúl Beltrán‐Debón, Esther Rodríguez‐Gallego, Montserrat Pinent, Ximena Terra, Anna Ardévol   +11 more
wiley   +1 more source

Assessment of short-term outcome with TiO2 mesh in laparoscopic repair of large paraesophageal hiatal hernias

BMC Surgery, 2019
Background Laparoscopic large para-oesophageal hiatal hernia (LPHH) repair using mesh reinforcement significantly reduces postoperative recurrence rates compared to conventional suture repair, especially within short follow-up times.
Islam Khaled, Pablo Priego, Mohammed Faisal, Marta Cuadrado, Francisca García-Moreno, Araceli Ballestero, Julio Galindo, Eduardo Lobo   +7 more
doaj   +1 more source

Effect of Zoledronic Acid on Skeletal Muscle After Bariatric Surgery: A Secondary Analysis From a Randomized Controlled Trial

Obesity, EarlyView.
ABSTRACT Objective This study aimed to investigate whether a single infusion of 5 mg zoledronic acid, given before bariatric surgery to prevent bone loss, could also hinder the loss of muscle mass, strength, and physical function. Methods In this double‐blinded study, patients referred for bariatric surgery were randomized 1:1 to either intervention ...
Søren Gam, Anne Pernille Hermann, Claus Bogh Juhl, Stinus Gadegaard Hansen, Bibi Gram   +4 more
wiley   +1 more source

Mechanisms Underlying Weight Loss and Metabolic Improvements in Rodent Models of Bariatric Surgery [PDF]

, 2014
Obesity is a growing health risk with few successful treatment options and fewer still that target both obesity and obesity-associated comorbidities. Despite ongoing scientific efforts, the most effective treatment option to date was not developed from ...
Arble, Deanna M., Sandoval, Darleen A., Seeley, Randy J.   +2 more
core   +2 more sources

A Randomized, Double‐Blind, Placebo‐Controlled Pilot Trial With Open‐Label Extension of Sirona, a Hydrogel for Weight Loss

Obesity, EarlyView.
ABSTRACT Objective This study investigated the safety, tolerability, and preliminary efficacy of Sirona, a novel gastro‐retentive, dual‐network polymer for weight management. Methods This pilot trial comprised a randomized, parallel‐group, double‐blind, placebo‐controlled (3:1 ratio), 12‐week period, with a 12‐week open‐label extension (OLE), in ...
James P. Byrne, Elanor C. Hinton, Asif Malik Humayun, Dimitri J. Pournaras, Rebecca L. Elsworth, Jeffrey M. Brunstrom, Julian P. Hamilton‐Shield, Mark Sumeray, Camilla Easter, Hutan Ashrafian   +9 more
wiley   +1 more source

Experiences of obesity among Saudi Arabian women contemplating bariatric surgery: An interpretative phenomenological analysis [PDF]

, 2013
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2013 The Authors.This study explored experiences of obesity, its perceived causes and motives for surgery, as described by seven Saudi ...
Aboud FE, Al-Tawil N, Albassam R, Cooke L, Musaiger A, Rabie M, Smith J   +6 more
core   +1 more source

People With Lowest Physical Functioning Scores Showed Greatest Improvement After Tirzepatide Treatment

Obesity, EarlyView.
ABSTRACT Objective This post hoc analysis of SURMOUNT trials assessed the association of baseline physical function (PF) with obesity‐related complications (ORCs), efficacy measures, and PF. The mechanism of tirzepatide‐led improvements in PF was evaluated. Methods Outcomes were assessed among participants (SURMOUNT‐1 = 2539; SURMOUNT‐3 = 579; SURMOUNT‐
Xuan Li, Dachuang Cao, Helene Sapin, Fangyu Wang, Theresa Hunter Gibble, Nedina Kalezic Raibulet, Max Denning, Lee M. Kaplan   +7 more
wiley   +1 more source

Quality of Life Following Massive Weight Loss and Body Contouring Surgery: an Exploratory Study. [PDF]

, 2012
Reconstructive surgery is a major growth intervention for body improvement, enhancing appearance and psychological well-being following massive weight loss.
Gilmartin, J, Long, AF, Soldin M
core  

GLP‐1 Receptor Agonists for Obstructive Sleep Apnea: An Otolaryngologist's Prescription?

The Laryngoscope, EarlyView.
Alina Zgardau, Ryan Chin Taw Cheong, Kenny Peter Pang, Brian W. Rotenberg   +3 more
wiley   +1 more source