Results 121 to 130 of about 15,465 (199)
Impact of Albuminuria‐Lowering Treatments on Cardiovascular Predictive Ceramides in Diabetes: Post Hoc Analysis of the ROTATE Trials
Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9346-9355, October 2026.ABSTRACT Aim
Cardiovascular disease (CVD) is the leading cause of mortality in individuals with diabetes. Diabetic kidney disease, closely related to CVD risk, is prevalent in up to 40% of this population. Emerging evidence suggests ceramide lipids as accurate biomarkers for CVD.Kristina Pigsborg, Simon Maria Kienle, Asger Wretlind, Viktor Rotbain Curovic, Martin Bæk Blond, Hiddo J. L. Heerspink, Tine Willum Hansen, Frederik Persson, Karolina Sulek, Cristina Legido‐Quigley, Peter Rossing +10 morewiley +1 more sourcePhase IIB, Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in COVID‐19
European Journal of Haematology, Volume 117, Issue 4, Page 922-935, October 2026.ABSTRACT Introduction
Endothelial dysfunction is key in COVID‐19 pathogenesis. This randomized, double‐blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS‐CoV‐2 infection and respiratory failure.Ruben Jara Rubio, Antonio José Martinez‐Mellado, Jonathan Kiwitt‐Cárdenas, José G. Clavel, Bartolomé García‐Perez, Pedro Castro, Maribel Diaz‐Ricart, Andrés Carrillo‐Alcaraz, Amparo López‐Bernús, Enrique Bernal Morell, Aychel Roura, Sonia Marín, Francisco‐José Ruiz‐López, Elena Solana‐Martinez, Domingo Martinez‐Baño, Carlos L. Albacete Moreno, Enriqueta Andreu Soler, Adrián Tellez Santoyo, Sara Fernández Méndez, Jose A. Noguera Velasco, Iria Cebreiros Lopez, Andrés Parrilla, Alberto Espuny‐Miró, David García‐Bernal, Miguel Blanquer, Andrés Sánchez‐Salinas, Francisca Iniesta, Cristina Hernandez Garcia, Manuel Muro, Alfredo Minguela Puras, Antonio Moreno‐Docón, Alberto M. Torres‐Cantero, Maria Munoz Garcia, Manuel Serrano, Massimo Iacobelli, Carmelo Carlo‐Stella, Lee‐Jen Wei, Paul G. Richardson, José M. Moraleda +38 morewiley +1 more sourceLonger-term safety and efficacy of baricitinib for atopic dermatitis in pediatric patients 2 to <18 years old: a randomized clinical trial of extended treatment to 3.6 years
Journal of Dermatological TreatmentBackground Baricitinib, an oral selective Janus kinase inhibitor, improved clinical signs and symptoms of moderate-to-severe atopic dermatitis (AD) at week 16 in the phase 3 pediatric study BREEZE-AD-PEDS.Objective To assess longer-term efficacy and ...Andreas Wollenberg, Masanori Ikeda, Chia-Yu Chu, Lawrence F. Eichenfield, Marieke M. B. Seyger, Apurva Prakash, Robinette Angle, Danting Zhu, Marco Pontes, Amy S. Paller +9 moredoaj +1 more sourceEpidemiology, Diagnosis and Management of Alopecia Areata: An Asia‐Pacific Modified Delphi Expert Panel Recommendations
International Journal of Dermatology, Volume 65, Issue 10, Page 2091-2101, October 2026.A panel of 18 dermatologists participated in a three‐round Delphi‐based consensus process to generate a standardized framework for the diagnosis and management of alopecia areata (AA) in Asia Pacific. Recommendations focus on practicality and clinical relevance within the regional context.Rodney Sinclair, Chao‐Chun Yang, Wen‐Hung Chung, Rachita Dhurat, Anil Ganjoo, Saranya Khunkhet, Jinran Lin, Anchala Parthasaradhi, Hyun‐Tae Shin, Kihyuk Shin, Poonkiat Suchonwanit, Kian Teo Tan, Jyh Jong Tang, Wenyu Wu, Felix Boon‐Bin Yap, Leona Yip, Angeline Yong, Cheng Zhou +17 morewiley +1 more sourceEfficacy and safety of baricitinib in 446 patients with rheumatoid arthritis: a real-life multicentre study
, 2021 Baricitinib, an oral Janus kinase (JAK) 1-2 inhibitor, is currently used along biologic DMARDs (bDMARDs) after the failure of methotrexate (MTX) in rheumatoid arthritis (RA).Riva, Marta, Birra, Domenico, De Vita, Salvatore, Viapiana, Ombretta, Luciano, Nicoletta, Quartuccio, Luca, Bazzani, Chiara, Canziani, Lorenzo Maria, Pozzi, Maria Rosa, Guidelli, Giacomo Maria, Chimenti, Maria Sole, Perricone, Roberto, De Santis, Maria, Selmi, Carlo, Boffini, Nicola, Bianchi, Gerolamo, Frediani, Bruno, Limonta, Massimiliano, Conticini, Edoardo, Gorla, Roberto, Moscato, Paolo, Bruschi, Eleonora, Rossini, Maurizio, Dagna, Lorenzo +23 morecore Large‐scale meta‐analysis of infection risk with JAK–STAT inhibitors in 29,000 patients
Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 10, Page 1662-1674, October 2026.In this large meta‐analysis of 74 randomized controlled trials involving more than 29,000 patients, JAK–STAT inhibitors were associated with an increased risk of influenza, bronchitis and herpes infections, particularly herpes zoster, while an increased risk of serious opportunistic or fungal infections was not observed.Máté Krebs, Lili Gulyás, Karen Krisztina Fazekas, Benedek Nagy, Mária Veronika Kolonics, Fanni Adél Meznerics, Norbert Kiss, András Bánvölgyi, Péter Hegyi, Péter Holló, Lajos Vince Kemény +10 morewiley +1 more sourceImmune checkpoint inhibitor‐induced eosinophilic fasciitis: A pharmacovigilance and EADV Task force study
Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 10, Page 1702-1712, October 2026.A comprehensive retrospective analysis of 121 immune checkpoint inhibitor‐induced eosinophilic fasciitis cases, including clinical presentation, diagnostic features and treatment outcomes using data from the EADV Task Force ‘Dermatology for Cancer Patients’, two international pharmacovigilance databases and the current literature.Tristan V. M. Bruijn, Alexandre O. Gérard, Maëlys Labat, Zoe Apalla, Wouter van Binsbergen, Dimitra Koumaki, Valerian Rivet, Frederic Dezoteux, Damien Giacchero, Michael R. Ardern‐Jones, Kara Heelan, Jesse P. Hirner, Ander Mayor, Mariette Labots, Markus V. Starink, Conny J. van der Laken, Vincent Sibaud, Yannick S. Elshot +17 morewiley +1 more sourceβ-Cell Function and Diabetes Outcomes 1 Year After Stopping Oral Baricitinib Immunotherapy for Type 1 Diabetes
OBJECTIVE
The Baricitinib in New-Onset Type 1 Diabetes (BANDIT) trial showed that baricitinib treatment for 48 weeks preserved β-cell function and lowered insulin requirements and glucose in recent-onset type 1 ...Jessica E. Harbison, Jane Keenan, Jennifer J. Couper, Candice Hall, Helen Thomas, Renee Kludas, Sara Vogrin, Peter Colman, Laura Sanz-Villanueva, Alexandra Gorelik, Jessica Harbison, Leanne Redl, Nicole Kruger, Lisa Kuspira, Prerak Trivedi, Baricitinib in New-Onset Type 1 Diabetes (BANDIT) Study Group:, Dao Hoa Anh Huynh, Madeleine Masterton, Helen E. Thomas, Maria Craig, Fergus Cameron, Richard MacIsaac, Felicity Healy, Fergus J. Cameron, Leonard C. Harrison, Stephan Mynhardt, Thomas Kay, Richard J. MacIsaac, Katherine Woods, Elizabeth Mulrooney, John M. Wentworth, Len Harrison, Joe Sasadeusz, Rebecca Gebert, Madeleine Doyle, Mandy Anderson, Tara Catterall, Gabby Atlas, Sara Litwak, Peter G. Colman, Vicky Gonzalez, Moses Mwangi, Anouk Koopman-Daemen, Michelle So, Sarah Lee, Bala Krishnamurthy, Stuart Mannering, Thomas W.H. Kay, Tom Brodnicki, John Wentworth, Kirsty Herewane, Balasubramanian Krishnamurthy, Kate Murphy, Michaela Waibel, Wing Fai Nip, Madeleine Hall, Jennifer Couper +56 morecore +1 more source