Results 81 to 90 of about 1,221,418 (303)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Research on Optimization of Barrier-Free Accessibility in Guangzhou Metro Stations - A Case Study of Xilang Station on Guangzhou Metro Line 1

Chengshi guidao jiaotong yanjiu
ObjectiveTo enhance the inclusiveness and circulation efficiency of Guangzhou metro stations and to identify potential deficiencies in the spatial organization of existing barrier-free paths, it is necessary to conduct an accessibility study on the ...
Xin CHEN, Bo XIA, Beini WANG, Huanchen ZHAO, Xun YANG   +4 more
doaj   +1 more source

Time-Sequential Working Wavelength-Selective Filter for Flat Autostereoscopic Displays

Applied Sciences, 2017
A time-sequential working, spatially-multiplexed autostereoscopic 3D display design consisting of a fast switchable RGB-color filter array and a fast color display is presented. The newly-introduced 3D display design is usable as a multi-user display, as
René de la Barré, Roland Bartmann, Silvio Jurk, Mathias Kuhlmey, Bernd Duckstein, Arno Seeboth, Detlef Lötzsch, Christian Rabe, Peter Frach, Hagen Bartzsch, Matthias Gittner, Stefan Bruns, Gerhard Schottner, Johanna Fischer   +13 more
doaj   +1 more source

Mechanical Metamaterials with Negative Compressibility Transitions

, 2012
When tensioned, ordinary materials expand along the direction of the applied force. Here, we explore network concepts to design metamaterials exhibiting negative compressibility transitions, during which a material undergoes contraction when tensioned ...
AC Pigou, Adilson E. Motter, AL Goodwin, B Moore, D Braess, D Schurig, DA Fortes, DR Smith, EV Vakarin, G Puglisi, GJ Martyna, HC Andersen, HMYC Mallikarachchi, JB Pendry, JE Cohen, JN Grima, K Otsuka, LE Reichl, MJ Beckmann, N Fang, O Mishima, PA Janmey, R Abeyaratne, R Gatt, RA Shelby, RH Baughman, RH Baughman, RS Lakes, RS Lakes, S Zhang, T Jaglinski, T Roughgarden, VG Veselago, Y Lee, Z Liu, Zachary G. Nicolaou   +35 more
core   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Ageing-in-place : home enhancement to give elderly a dream home

, 2015
Everyone has their own definition of dream home , but there is always something in common - comfort and safety. Seniors prefer to stay in their own house for as long as possible, yet the inevitable decline of their physical functionality in the process ...
CHAN, Man Yin, Emily
core  

Reducing the Barrier to Entry of Complex Robotic Software: a MoveIt! Case Study

, 2014
Developing robot agnostic software frameworks involves synthesizing the disparate fields of robotic theory and software engineering while simultaneously accounting for a large variability in hardware designs and control paradigms.
Chitta, Sachin, Coleman, David, Correll, Nikolaus, Sucan, Ioan   +3 more
core   +1 more source