Results 51 to 60 of about 704,523 (264)

Barrier Methods of Contraception [PDF]

JAMA: The Journal of the American Medical Association, 1987
Although a recent Cavalieri dOro et al. article correctly concludes that while barrier methods reduce the risk of gonorrhea and HIV they may be less consistent for other diseases the review does not include the female condom the newest method of barrier contraception.
openaire   +2 more sources

Storm surge barrier performance—The effect of barrier failures on extreme water level frequencies

Journal of Flood Risk Management
Sea level rise necessitates the upgrade of coastal flood protection including storm surge barriers. These large movable hydraulic structures are open in normal conditions, but close during a storm surge to prevent coastal floods in bays and estuaries ...
L. F. Mooyaart, A. M. R. Bakker, J. A. van denBogaard, R. E. Jorissen, T. Rijcken, S. N. Jonkman   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Correcting Inconsistency in Linear Inequalities by Minimal Change in the Right Hand Side Vector [PDF]

Computer Science Journal of Moldova, 2009
Correcting an inconsistent set of linear inequalities by minimal changes in problem data is a well studied problem and up to now several algorithms have been developed to do this task. In this paper, we consider doing the minimal correction using the l 2
Saeed Ketabchi , Maziar Salahi
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Combined acoustical and economical noise barrier optimization using genetic algorithms

Građevinar, 2019
This paper studies noise barrier optimization using the Boundary Element Method (BEM) as a numerical technique and Genetic Algorithms (GA). Noise barriers are optimised according to acoustical, technological and economical properties so as to obtain an ...
Antonio Petošić, Mia Suhanek, Ivan Đurek, Sanja Grubeša   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Maximising mosquito collections from barrier screens: the impacts of physical design and operation parameters

Parasites & Vectors, 2019
Background Traditional methods for collecting outdoor resting mosquitoes are generally inefficient with relatively low numbers caught per unit effort. The barrier screen, designed to intercept mosquitoes as they fly between areas where blood meals are ...
Edgar J. M. Pollard, Tanya L. Russell, Thomas R. Burkot   +2 more
doaj   +1 more source