Results 251 to 260 of about 1,327,323 (292)
Some of the next articles are maybe not open access.
Nanotechnologies: A Strategy to Overcome Blood-Brain Barrier
Current Drug Metabolism, 2012The possibility to treat central nervous system (CNS) disorders is strongly limited by the poor access of many therapeutic agent to the target tissues. This is mainly due to the presence of the blood-brain barrier (BBB), formed by a complex interplay of endothelial cells, astrocyte and pericytes, through which only selected molecules can passively ...
De Rosa G +3 more
openaire +5 more sources
Strategy for the Foundation Design of Rockfall Barriers
2015European Technical Approval Guideline (ETAG 027) defines the functionality of a rockfall barrier and describes all the procedure to carry out the full scale tests and consequently outline the deformability, the resistance, the performances and the forces acting on the foundations of a deformable rockfall fence.
Giacchetti, Giorgio +2 more
openaire +2 more sources
Minimal Patching Barrier Healing Strategy for barrier coverage in hybrid WSNs
2014 IEEE 25th Annual International Symposium on Personal, Indoor, and Mobile Radio Communication (PIMRC), 2014Barrier coverage is a critical issue in Wireless Sensor Networks (WSNs) for various battlefield and homeland security applications. In this paper, we address the problem of how to efficiently heal coverage holes in hybrid Wireless Sensor Networks (WSNs) by relocating mobile nodes, and propose a hole recovery strategy called Minimal Patching Barrier ...
Menglong Li +2 more
exaly +2 more sources
Barriers to and Strategies for Faculty Integration of IT
2009At most institutions of higher education, faculty members wear many “hats.” Among other responsibilities, they are expected to teach, conduct research, and participate in institutional and public service. Within the teaching realm, faculty members have always had multiple responsibilities.
Thomas M. Brinthaupt +2 more
openaire +1 more source
Barriers affecting adherence to radiation treatment and strategies to overcome those barriers
Indian Journal of Cancer, 2017BACKGROUND: The WHO defines adherence as the extent to which a patient's behavior coincides with recommendations from a health-care provider. Nonadherence to cancer treatment has a major impact on the therapeutic outcome. AIM OF THE STUDY: To assess the prevalence of nonadherence to
R, Rangarajan, K, Jayaraman
openaire +2 more sources
Cell and Tissue Research, 2014
The blood-brain barrier (BBB) protects the brain from toxic substances within the bloodstream and keeps the brain's homeostasis stable. On the other hand, it also represents the main obstacle in the treatment of many CNS diseases. Among different techniques, nanoparticles have emerged as promising tools to enhance brain drug delivery of therapeutic ...
Rempe, Ralf +3 more
openaire +4 more sources
The blood-brain barrier (BBB) protects the brain from toxic substances within the bloodstream and keeps the brain's homeostasis stable. On the other hand, it also represents the main obstacle in the treatment of many CNS diseases. Among different techniques, nanoparticles have emerged as promising tools to enhance brain drug delivery of therapeutic ...
Rempe, Ralf +3 more
openaire +4 more sources
Barriers to entry and competitive strategies
Strategic Management Journal, 1981Abstract The relationships between the difficulty of entry and competitive strategies in five industries, chosen for their differing structural contexts, were tested. Statistical support was found for the value of pre‐entry analysis of entry barriers and of firms' predicted responses to potential entry.
openaire +1 more source
Barriers to Strategy Implementation and Their Links with Strategy Typologies
2019จุฬาลงกรณ์ธุรกิจปริทัศน์, 41, 161, 102 ...
openaire +1 more source
Strategies to assess blood–brain barrier penetration
Expert Opinion on Drug Discovery, 2008The principles and screening strategies for brain penetration in drug discovery are important in identifying drug candidates with desirable CNS properties.Define key variables and assays that are essential for determining brain penetration.This review covers issues, methods, and strategies for assessing brain penetration of small molecules in drug ...
Li, Di, Edward H, Kerns, Guy T, Carter
openaire +2 more sources
Strategies to Overcome the Enzymatic Barrier
2009Enzymatic degradation of various hydrophilic macromolecules including peptide- or protein drugs by enzymes present in the gastrointestinal tract can be regarded as one main reason for their poor bioavailability after peroral administration. Within the current chapter, strategies to overcome the so-called enzymatic barrier are described.
Martin Werle, Hirofumi Takeuchi
openaire +1 more source