Results 71 to 80 of about 3,618,266 (313)

Barriers to cardiac rehabilitation delivery in a low-resource setting from the perspective of healthcare administrators, rehabilitation providers, and cardiac patients [PDF]

, 2019
Background: Despite clinical practice guideline recommendations that cardiovascular disease patients participate, cardiac rehabilitation (CR) programs are highly unavailable and underutilized. This is particularly true in low-resource settings, where the
Britto, Raquel, da Silva, Lilian Pinto, Duarte Novais Silva, Luciana, Grace, Sherry L., Lima de Melo Ghisi, Gabriela, Lima, Márcia Maria Oliveira, Pereira, Danielle Aparecida Gomes, Sérvio, Thaianne Cavalcante   +7 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Head‐to‐head comparison between ACQ and FRET in probing polymeric micelles

View
Environmentally responsive fluorophores, such as those with aggregation‐caused quenching (ACQ) and Förster resonance energy transfer (FRET) properties, are widely used to track nanocarriers while minimizing artifacts.
Runtong Zhang, Chang Liu, Ruonan Lu, Yuanmei Yang, Zichen Zhang, Yifan Cai, Haisheng He, Yi Lu, Aun Raza, Wei Wu   +9 more
doaj   +1 more source

TrkB-enhancer facilitates functional recovery after traumatic brain injury

Scientific Reports, 2017
Brain-derived neurotrophic factor (BDNF), a key player in regulating synaptic strength and learning, is dysregulated following traumatic brain injury (TBI), suggesting that stimulation of BDNF signaling pathways may facilitate functional recovery.
John Marshall, Joanna Szmydynger-Chodobska, Mengia S. Rioult-Pedotti, Kara Lau, Andrea T. Chin, Siva K. Reddy Kotla, Rakesh Kumar Tiwari, Keykavous Parang, Steven W. Threlkeld, Adam Chodobski   +9 more
doaj   +1 more source

Endothelial Barrier Function.

Journal of Investigative Dermatology, 1989
The endothelial barrier in all organ beds allows the free exchange of water, but is restrictive to varying degrees to the transport of solutes such as albumin. For example, in the brain microvessels, the endothelial barrier restricts the transport of protein, whereas in fenestrated and continuous endothelial cells of the renal and lung endothelial ...
A B, Malik, J J, Lynch, J A, Cooper
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Barriers to Professional Mental Health Help-Seeking Among Chinese Adults: A Systematic Review

Frontiers in Psychiatry, 2020
BackgroundA large number of Chinese suffer from common mental disorders (e.g., depression, anxiety, stress, and post-traumatic stress disorder), but treatment seeking is typically low in this population. It is unclear what barriers influence professional
Wei Shi, Zhuozhuo Shen, Siyuan Wang, Brian J. Hall   +3 more
doaj   +1 more source

Factors Influencing Household Solar Adoption in Santiago, Chile

, 2018
In Santiago, Chile, the market conditions are seemingly excellent for the household adoption of photovoltaic (PV) technology, yet the uptake is negligible.
Huepe, Claudio, Kaminsky, Jessica, Walters, Jeffrey P.   +2 more
core   +1 more source

Fast beam stacking using RF barriers [PDF]

, 2007
Two barrier RF systems were fabricated, tested and installed in the Fermilab Main Injector. Each can provide 8 kV rectangular pulses (the RF barriers) at 90 kHz. When a stationary barrier is combined with a moving barrier, injected beams from the Booster
/Fermilab, Capista, D., Chou, W., Griffin, J., Ng, K.-Y., Wildman, D.   +5 more
core   +2 more sources