Results 11 to 20 of about 9,044 (128)

Effects of Cannabidiol on TAFAZZIN-Deficient B-Lymphoblastoid Cells. [PDF]

FASEB J
Deficiency of the cardiolipin remodeling enzyme TAFAZZIN causes Barth syndrome (BTHS), resulting in cardiolipin loss, monolysocardiolipin (MLCL) accumulation, and electron transport chain (ETC) abnormalities in B‐lymphoblastoid cells. Effects of the non‐psychotropic phytocannabinoid cannabidiol (CBD) were examined on B‐lymphoblastoid cells from ...
Chan JZ, Berdeklis AN, Liu MR, Rahman FA, Tomczewski MV, Graham MQ, Musa M, Cocco AD, Stark KD, Quadrilatero J, Duncan RE.   +10 more
europepmc   +2 more sources

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases. [PDF]

Adv Sci (Weinh)
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Singh P, Tahavvori A, Kuschner CE, Espin BB, Kazmi J, Ramos SV, Yin T, Hayashida K, Ito-Hagiwara K, Endo Y, Yoshioka K, Hagiwara J, Sohi A, Oropallo A, Haddad G, Li T, Becker LB, Kim J.   +17 more
europepmc   +2 more sources

Development and Validation of the Brief Inventory of Treatment Expectations in Chronic Pain (BITEC). [PDF]

Eur J Pain
ABSTRACT Background Expectations shape therapeutic outcomes, yet their systematic assessment remains limited in clinical and research settings. To address this gap, we developed and validated the Brief Instrument for the Assessment of Treatment Expectations in Chronic Pain (BITEC) using Item Response Theory. Methods The study comprised four phases. (I)
Caumo W, França BR, Ehlers J, de Jezus Castro SM, Borges RB, Hirakata VN, Bueno GB, da Torres IL, Fregni F.   +8 more
europepmc   +2 more sources

Multidimensional treatment foster care for preschoolers: early findings of an implementation in the Netherlands [PDF]

, 2012
Multidimensional Treatment Foster Care (MTFC) has been shown to be an evidence based alternative to residential rearing and an effective method to improve behavior and attachment of preschool foster children in the US. This preliminary study investigated
American Psychiatric Association, AT Smyke, AT Smyke, AT Smyke, CA Nelson, Carlo Schuengel, Caroline S Jonkman, CB Lanktree, CH Zeanah, D Fanshel, DM Rubin, Eva A Bolle, FC Verhulst, Frits Boer, GA Aarons, GR Patterson, H Minnis, HM Koot, JB Patterson GR Reid, KC Pears, KC Stovall, M Oosterman, Mirjam Oosterman, P Chamberlain, P Chamberlain, P Chamberlain, P Curtis, P Kohl, PA Fisher, PA Fisher, PA Fisher, PK Westermark, Ramon JL Lindauer, Robert Lindeboom, SH Oswald, T Besier, TM Achenbach, TM Achenbach   +37 more
core   +7 more sources

Practical Recommendations of the Obesity Management Task Force of the European Association for the Study of Obesity for the Post-Bariatric Surgery Medical Management [PDF]

, 2017
Bariatric surgery is today the most effective long-term therapy for the management of patients with severe obesity, and its use is recommended by the relevant guidelines of the management of obesity in adults.
Azran, Carmil, Batterham, Rachel L, Busetto, Luca, Dicker, Dror, Farpour-Lambert, Nathalie, Fried, Martin, Hjelmes\ue6th, J\uf8ran, Kinzl, Johann, Leitner, Deborah R, Makaronidis, Janine M, Schindler, Karin, Toplak, Hermann, Yumuk, Volkan   +12 more
core   +6 more sources

Effects of mavoglurant on visual attention and pupil reactivity while viewing photographs of faces in Fragile X Syndrome. [PDF]

, 2019
BackgroundNumerous preclinical studies have supported the theory that enhanced activation of mGluR5 signaling, due to the absence or reduction of the FMR1 protein, contributes to cognitive and behavioral deficits in patients with fragile X syndrome (FXS).
Berry-Kravis, Elizabeth, Chin, Jamie, Crestodina, Crystal, Hagerman, Randi J, Harvey, Danielle, Hessl, David, Joshi, Reshma, Sansone, Stephanie   +7 more
core   +2 more sources

Insomnia as an Independent Predictor of Incident Cardiovascular Disease in HIV: Data from the Veterans Aging Cohort Study [PDF]

, 2019
Background: Insomnia is associated with increased cardiovascular disease (CVD) risk in the general population and is highly prevalent in people with HIV. The CVD risk conferred by insomnia in the HIV population is unknown.
Bedimo, Roger J., Budoff, Matthew J., Butt, Adeel A., Chang, Chung-Chou H., Freiberg, Matthew S., Gottlieb, Stephen S., Gupta, Samir K., Kundu, Suman, Marconi, Vincent C., Polanka, Brittanny M., So-Armah, Kaku A., Stewart, Jesse C., Womack, Julie A.   +12 more
core   +1 more source

Meditation awareness training for the treatment of fibromyalgia syndrome: A randomized controlled trial [PDF]

, 2016
Objectives: The purpose of this study was to conduct the first randomised controlled trial to evaluate the effectiveness of a second-generation mindfulness-based intervention (SG-MBI) for treating fibromyalgia syndrome (FMS). Compared to first-generation
Baguley, Baguley, Baron, Bennett, Boutron, Branco, Buysse, Canzonieri, Davis, Faul, Feliu-Soler, Garcia-Martin, Gelman, Glombiewski, Goyal, Grossman, Hawker, Henke, Hutcherson, Häuser, Jones, Kabat-Zinn, Kabat-Zinn, Kaplan, Langhorst, Lauche, Leiberg, Leys, Lovibond, Luciano, MacCoon, Mannerkorpi, Mease, Melzack, Modrego, Moreira-Almeida, Morone, Nüesch, Purser, Quené, Sahdra, Sahdra, Schaefer, Schulz, Scott, Segal, Shonin, Shonin, Shonin, Shonin, Shonin, Shonin, Sicras-Mainar, Snijders, Van Gordon, Van Gordon, Van Gordon, Van Gordon, Van Gordon, Van Gordon, Weissbecker, Wolfe, Wolfe, Wolfe   +63 more
core   +1 more source

Clinical application of ceramics in anterior cervical discectomy and fusion: A review and update [PDF]

, 2017
Study Design: Narrative review. Objectives: Anterior cervical discectomy and fusion (ACDF) is a reliable procedure, commonly used for cervical degenerative disc disease. For interbody fusions, autograft was the gold standard for decades; however, limited
Abedi, Aidin, Bonaki, Hirbod, Jazayeri, Seyed B., Rahimi-Movaghar, Vafa, Vaccaro, Alex R., Zadegan, Shayan A.   +5 more
core   +2 more sources

Task-dependent Modulation of Cortical Excitability and Balance Control in Individuals with Post-concussion Syndrome [PDF]

, 2017
In most cases, symptoms resolve between 7-10 days post-concussion. However, in 10-15% of the concussed population, symptoms can remain unresolved for months to years following the head injury.
Cinelli, Michael E, Mr, Kalmar, Jayne M, Ms., Kaster, Kristen   +2 more
core   +1 more source