Results 161 to 170 of about 984,029 (267)

Mitochondrial dysfunction drives basal cell hyperplasia in eosinophilic oesophagitis. [PDF]

Gut
Morimoto M, Kawasaki K, McNamee N, Flashner S, Shimonosono R, Shimonosono M, Matsuura N, Tomita Y, Hirose W, Teranishi R, Itami T, Guha M, Rajagopalan P, Martin C, Golden H, Dhakal D, Wilkins BJ, Klein-Szanto AJ, Wangensteen KJ, Abrams JA, Pomenti S, Katzka DA, Que J, Whelan KA, Muir AB, Kita H, Wright BL, Doyle AD, Nakagawa H, Sachdeva UM.   +29 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer. [PDF]

Nature
Ireland AS, Xie DA, Hawgood SB, Barbier MW, Zuo LY, Hanna BE, Lucas-Randolph S, Tyson DR, Witt BL, Govindan R, Dowlati A, Moser JC, Thomas A, Puri S, Rudin CM, Chan JM, Elliott A, Oliver TG.   +17 more
europepmc   +1 more source

Development of high-performance roll-to-roll-coated gas-diffusion-electrode-based fuel cells

, 2021
Scott A Mauger, Min Wang, Firat C. Cetinbas, Michael J. Dzara, Jae Hyung Park, Deborah J. Myers, Rajesh Ahluwalia, Svitlana Pylypenko, Leiming Hu, Shawn Litster, K.C. Neyerlin, Michael Ulsh   +11 more
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Myoepithelial Carcinoma Mimicking Basal Cell Carcinoma: A Case Report. [PDF]

Cureus
Asharaff F, Nayak N, Webb R, Moutasim K, Lalla S.   +4 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Basal Cell Carcinoma of the Cloacal Aperture in a Red Kangaroo (<i>Osphranter rufus</i>). [PDF]

Vet Sci
van der Weyden L, Fitte A, O'Dell N.
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Basal cell carcinoma risk prediction in survivors of childhood cancer. [PDF]

J Natl Cancer Inst
Im C, Boull C, Lu Z, Liao K, Hasan H, Xu L, Sapkota Y, Howell RM, Arnold MA, Conces MR, Housten AJ, Gebauer J, Langer T, Teepen JC, Kremer LCM, Constine LS, Yasui Y, Hudson MM, Ness KK, Armstrong GT, Neglia JP, Yuan Y, Turcotte LM.   +22 more
europepmc   +1 more source