Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li +12 more
wiley +1 more source
Prognostic Factors in the Management of Basal Cell Carcinoma: A Single-Center Experience. [PDF]
Bozkurt F +3 more
europepmc +1 more source
Basal cell carcinoma. Case presentation
Yusdenia G. Soto Serrano +3 more
openalex +1 more source
Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen +4 more
wiley +1 more source
Comparative Analysis of Reflectance Confocal Microscopy and Multiphoton Microscopy in Basal Cell Carcinoma Diagnosis. [PDF]
Zhong W, Long L, Feng Y, Han X, Chen J.
europepmc +1 more source
This study describes a T cell surface engineering strategy that integrates polymer materials with tumor immunology, aiming to achieve broad‐spectrum anti‐tumor applications of glycopolymer‐engineered T (G‐T) cells via non‐genetic modification. Glycopolymer engineering generally modulates immune‐tumor crosstalk through specific cell‐cell interactions ...
Lihua Yao +8 more
wiley +1 more source
Search Trends for Skin Cancers: Associations of Basal Cell Carcinoma, Squamous Cell Carcinoma, and Melanoma With Socioeconomic Indicators, Geography, and Awareness Campaigns. [PDF]
Solak B, Sepetci MS.
europepmc +1 more source
TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang +16 more
wiley +1 more source
Dual‐stimuli‐responsive CuFeTe2 nanosheets (CFT) induce cuproptosis/ferroptosis via TME‐responsive Fe2⁺/Cu2⁺ release and NIR‐II photothermal effects, amplifying ROS and depleting HSP70/ATP to trigger ICD and immune activation, while ensuring biocompatible renal clearance for TNBC therapy.
Molin Liu +14 more
wiley +1 more source
Expression analysis of NOD-like receptor protein 3 and interleukin-18 in basal cell carcinoma: A case-control study. [PDF]
Mehrabi Z +6 more
europepmc +1 more source

