Results 61 to 70 of about 2,786,772 (398)

Gorlin syndrome in a patient with skin type VI [PDF]

, 2019
Gorlin syndrome, also known as nevoid basal cell carcinoma syndrome, is a rare autosomal dominant disorder that is characterized by multiple basal cell carcinomas developing at a young age, keratocystic odontogenic tumors of the jaw, palmar or plantar ...
Anderson, Kathryn L, Difato, Thomas C, Poladian, Katlin, Taylor, Sarah L   +3 more
core  

Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer. [PDF]

, 2016
1,25 dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D, and calcium regulate epidermal differentiation. 1,25(OH)2D exerts its effects through the vitamin D receptor (VDR), a transcription factor in the nuclear hormone receptor family ...
Bikle, Daniel D, Jiang, Yan, Nguyen, Thai, Oda, Yuko, Tu, Chia-Ling   +4 more
core   +2 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Expression of heparanase in basal cell carcinoma and squamous cell carcinoma [PDF]

Anais Brasileiros de Dermatologia, 2016
: Background: Heparanase is an enzyme that cleaves heparan sulfate chains. Oligosaccharides generated by heparanase induce tumor progression. Basal cell carcinoma and squamous cell carcinoma comprise types of nonmelanoma skin cancer.
Maria Aparecida Silva Pinhal, Maria Carolina Leal Almeida, Alessandra Scorse Costa, Thérèse Rachell Theodoro, Rodrigo Lorenzetti Serrano, Carlos D'Apparecida Santos Machado Filho   +5 more
doaj   +1 more source

Tumor site immune markers associated with risk for subsequent basal cell carcinomas. [PDF]

, 2011
BackgroundBasal cell carcinoma (BCC) tumors are the most common skin cancer and are highly immunogenic.ObjectiveThe goal of this study was to assess how immune-cell related gene expression in an initial BCC tumor biopsy was related to the appearance of ...
Andridge, Rebecca, Bechtel, Mark A, Chen, Min, De Renne, Lawrence A, Di Gregorio, Michael, Glaser, Ronald, Hearne, Dean W, Herron, Joel Bain, Jewell, Scott D, Johnson, Sheri L, Kiecolt-Glaser, Janice K, Lambert, David R, Shana'ah, Arwa Y, Yang, Eric V   +13 more
core   +2 more sources

Accuracy of mobile digital teledermoscopy for skin self-examinations in adults at high risk of skin cancer: an open-label, randomised controlled trial [PDF]

, 2020
Background: Skin self-examinations supplemented with mobile teledermoscopy might improve early detection of skin cancers compared with naked-eye skin self-examinations.
Avilés-Izquierdo, Baade, Berwick, Boyce, Chambers, Chao, Djaja, Genders, Hamidi, Janda, Janda, Janda, Kandel, King, Kroemer, Li, Luttrell, Manahan, Markun, Morze, Pike, Rat, Robinson, Tschandl, Venables, Wu   +25 more
core   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Chemoprevention of Basal and Squamous Cell Carcinoma With a Single Course of Fluorouracil, 5%, Cream: A Randomized Clinical Trial

JAMA dermatology, 2018
Importance Keratinocyte carcinoma (ie, cutaneous basal and squamous cell carcinoma) is the most common cancer in the United States. Objective To determine whether topical fluorouracil could prevent surgically treated keratinocyte carcinoma.
M. Weinstock, S. Thwin, J. Siegel, K. Marcolivio, A. Means, N. Leader, F. M. Shaw, D. Hogan, D. Eilers, S. Swetter, Suephy C. Chen, S. Jacob, E. Warshaw, G. Stricklin, R. Dellavalle, N. Sidhu-Malik, N. Konnikov, V. Werth, J. Keri, L. Robinson-Bostom, R. Ringer, R. Lew, Ryan E Ferguson, J. DiGiovanna, Grant D. Huang   +24 more
semanticscholar   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Basal cell carcinoma: PD-L1/PD-1 checkpoint expression and tumor regression after PD-1 blockade

Journal of Immunotherapy for Cancer, 2017
Monoclonal antibodies that block immune regulatory proteins such as programmed death-1 (PD-1) have demonstrated remarkable efficacy in controlling the growth of multiple tumor types.
E. Lipson, Mohammed T Lilo, Aleksandra Ogurtsova, Jessica Esandrio, Haiying Xu, P. Brothers, M. Schollenberger, W. Sharfman, J. Taube   +8 more
semanticscholar   +1 more source