Results 81 to 90 of about 2,786,772 (398)

Resistance to anti-PD-1-based immunotherapy in basal cell carcinoma: a case report and review of the literature

Journal of Immunotherapy for Cancer, 2018
BackgroundImmunotherapy with immune checkpoint inhibitors has radically changed the management of a broad spectrum of tumors. In contrast, only very limited information is available about the efficacy of these therapies in non-melanoma skin cancers ...
Francesco Sabbatino, A. Marra, Luigi Liguori, G. Scognamiglio, C. Fusciello, G. Botti, S. Ferrone, S. Pepe   +7 more
semanticscholar   +1 more source

Core promoter: A critical region where the hepatitis B virus makes decisions [PDF]

, 2014
The core promoter (CP) of the viral genome plays an important role for hepatitis B virus (HBV) replication as it directs initiation of transcription for the synthesis of both the precore and pregenomic (pg) RNAs.
Quarleri, Jorge Fabian
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Radiation-induced basal cell carcinoma

Dermatology Practical & Conceptual, 2015
Background: The treatment of tinea capitis using radiotherapy was introduced at the beginning of the twentieth century. A variety of cancers including basal cell carcinoma (BCC) are seen years after this treatment.
Omid Zargari
doaj   +1 more source

YAP and TAZ are essential for basal and squamous cell carcinoma initiation

EMBO Reports, 2018
YAP and TAZ are key downstream regulators of the Hippo pathway, regulating cell proliferation and differentiation. YAP and TAZ activation has been reported in different cancer types.
Maud Debaugnies, A. Sànchez-Dànes, S. Rorive, Maylis Raphaël, Mélanie Liagre, Marie-Astrid Parent, A. Brisebarre, I. Salmon, C. Blanpain   +8 more
semanticscholar   +1 more source

Vitamin D enzymes (CYP27A1, CYP27B1 and CYP24A1) and receptor expression in non-melanoma skin cancer [PDF]

, 2019
No abstract available for this ...
Apostolopoulos, Vasso, Blatch, Gregory L, Dass, Crispin R, Nemazannikova, Natalie, Sinclair, Rodney   +4 more
core   +2 more sources

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Metastatic basal cell carcinoma with atypical pattern of spread

Radiology Case Reports, 2020
Basal cell carcinoma is the most common malignancy in the United States. However, metastasis of basal cell carcinoma is exceedingly rare, with incidence estimates of 0.0028–0.055%.
Matthew Gellatly, BA, Estefanía Cruzval-O'Reilly, BA, Julie E. Mervak, MD, Benjamin M. Mervak, MD   +3 more
doaj   +1 more source

Basal cell carcinoma of the perineum [PDF]

Dermatology Online Journal, 2014
Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer. Most BCCs are found on areas of UV-damaged skin, The study of BCCs of sun-protected regions, however, suggests a more complex pathogenesis. We present a case of BCC of the perineum in a man with no previous history of skin cancer.
Levin, Adriane Ann, Dabade, Tushar, Dandekar, Monisha, Rogers, Gary, Rosmarin, David   +4 more
openaire   +4 more sources