Results 51 to 60 of about 5,363,743 (277)

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Transepithelial projections from basal cells are luminal sensors in pseudostratified epithelia [PDF]

, 2008
Basal cells are by definition located on the basolateral side of several epithelia, and they have never been observed reaching the lumen. Using high-resolution 3D confocal imaging, we report that basal cells extend long and slender cytoplasmic ...
McKee, Mary, Shum, Winnie Wai Chi, Breton, Sylvie, Brown, Dennis, Smith, Peter J.S., Da Silva, Nicolas   +5 more
core   +1 more source

Condyloma acuminatum: its histopathological pattern

São Paulo Medical Journal
Condyloma acuminatum is one of the clinical manifestations of papillomavirus infection. The classical histopathological features are already known and do not constitute a diagnostic problem. Clinically, it has been classified into growth or proliferative,
Eliane Pedra Dias, Ana Luisa Figueira Gouvêa, Claudia Carvalhal Eyer   +2 more
doaj   +1 more source

Phenotypic profle of monocyte-macrophage lineage cells as a function of respiratory epithelium status

Сибирский онкологический журнал, 2023
The mechanism of the relationship between pretumor changes in the bronchial respiratory epithelium and the risk of progression of non-small cell lung cancer (NSCLC) remains unclear.
A. A. Fedorov, N. A. Ermak, E. B. Topolnitskiy, N. A. Shefer, E. O. Rodionov, O. V. Pankova, N. V. Cherdyntseva, M. N. Stakheyeva   +7 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Effect of heat exposure on viability and contractility of cultured prostatic stromal cells [PDF]

, 2000
Objectives: Different thermotherapeutic modalities such as transurethral microwave therapy or transurethral needle ablation have been developed to provide effective alternatives to surgical management of benign prostate hyperplasia (BPH).
Corvin, Stefan, Maneschg, Christoph, Klocker, Helmut, Radmayr, Christian, Boesch, Simone, Bartsch, Georg   +5 more
core   +1 more source

Premalignant Changes in the Bronchial Epithelium Are Prognostic Factors of Distant Metastasis in Non-Small Cell Lung Cancer Patients

Frontiers in Oncology, 2021
BackgroundThe study assessed the possibility of dividing patients into groups based on the assessment of morphological changes in the epithelium of small-caliber bronchi located near the primary tumor in order to predict high and low risks of distant ...
Olga V. Pankova, Liubov A. Tashireva, Evgeny O. Rodionov, Sergey V. Miller, Sergey A. Tuzikov, Dmitry S. Pismenny, Tatiana S. Gerashchenko, Marina V. Zavyalova, Marina V. Zavyalova, Sergey V. Vtorushin, Sergey V. Vtorushin, Evgeny V. Denisov, Evgeny V. Denisov, Vladimir M. Perelmuter   +13 more
doaj   +1 more source

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source

Markers of Airway Remodeling in Bronchopulmonary Diseases

Zdorovʹe Rebenka, 2014
The article presents information about markers of airway remodeling in bronchopulmonary diseases. There is described the influence of matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase, transforming growth factor, collagen ...
O.Ye. Chernyshova
doaj   +1 more source

Dynamically Actuated Reconfigurable Topographical Surface Enables Active Control of Implant‐Associated Infections

Advanced Functional Materials, EarlyView.
A dynamically actuated reconfigurable topographical surface (DARTS) integrates contact‐mediated bactericidal nanotopography with programmable mechanical actuation to actively disrupt bacterial biofilms. Dynamic surface reconfiguration enhances bacterial killing and suppresses implant‐associated infections in vivo, providing a new strategy for active ...
Mohammad Asadi Tokmedash, Jihun Lee, J. Scott VanEpps, Sungmin Nam, Jouha Min   +4 more
wiley   +1 more source