Results 101 to 110 of about 99,722 (241)
Decision Making and the Brain: Neurologists' View [PDF]
The article reflects the fact, that concepts like decision making and free will have entered the field of cognitive neuroscience towards the end of 20th century. It gives an overview of brain structures involved in decision making and the concept of free
Dejan Georgiev +2 more
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American Journal of Medical Genetics Part A, EarlyView.ABSTRACT The MT‐ATP6 gene m.8993T>G pathogenic variant has been associated with Leigh syndrome, especially in patients exhibiting a high degree of heteroplasmy. Although patients may present with a wide phenotypic spectrum, characteristic findings include bilateral, symmetric hyperintensities in the basal ganglia and brainstem on brain MRI ...
Ramya Treitel +2 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.The present study investigates the role of the NLRP3 inflammasome in the chronicity of ocular inflammation in uveitis using the experimental autoimmune uveitis (EAU) model. Whole eyes collected from EAU mice, 12 weeks post induction, were sectioned and subjected to immunohistochemistry. The confocal images from these sections were then assessed for the
Avik Shome +3 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.Sydenham's chorea (SC) is the neurological manifestation associated with acute rheumatic fever (ARF), triggered by a group A streptococcal (GAS) infection. Anti‐GAS antibodies cross‐reacting with tissue proteins are implicated in the development of neurological changes. In this study, using an animal model, we demonstrate that a compromised blood–brain
Rukshan Ahamed Mohamed Rafeek +8 more
wiley +1 more source
Distinct Alterations of Inflammatory Biomarkers in Cluster Headache: A Case Control Study
Annals of Neurology, EarlyView.Objective Investigate the immune system's role in cluster headache by analyzing cytokines in people with cluster headache and headache‐free controls, and explore if certain cytokines could predict a specific phenotype. Methods We measured 45 cytokines in adult participants from the Danish Cluster Headache Biobank in a prospective case–control setup ...
Nunu Laura Timotheussen Lund +6 more
wiley +1 more source
Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies
Annals of Neurology, EarlyView.Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel +10 more
wiley +1 more source
The Anatomical Record, EarlyView.Abstract Hibernation induces significant molecular and cellular adaptations in the retina to maintain function under reduced metabolic conditions. This study aimed to investigate the expression of neuronal, synaptic, and glial markers in the retina of Spermophilus xanthoprymnus during pre‐hibernation and hibernation periods using immunohistochemical ...
Mehmet Özbek +5 more
wiley +1 more source
The Anatomical Record, EarlyView.Abstract Autonomic nerves are crucial in cardiac function and pathology. However, data on the distribution of cholinergic and noradrenergic nerves in normal and pathologic human hearts is lacking. Nonfailing donor hearts were pressure‐perfusion fixed, imaged, and dissected. Left ventricular cardiomyopathy samples were also obtained.
Peter Hanna +15 more
wiley +1 more source
Optimized AAV capsids for basal ganglia diseases show robust potency and distribution. [PDF]
Nat CommunLeib DE +13 more
europepmc +1 more source
American Journal of Medical Genetics Part A, Volume 197, Issue 7, July 2025.
Toru Nagata +6 more
wiley +1 more source