Results 111 to 120 of about 99,722 (241)

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Synthesis and biological characterization of 4,4‐difluoro‐3(phenoxymethyl)piperidine scaffold as dopamine 4 receptor (D4R) antagonist in vitro tool compounds

ChemMedChem, Accepted Article.
We report the discovery and characterization of a novel series of 4,4‐difluoropiperidine etherbased dopamine D4 receptor antagonists. Structure‐activity relationship studies led to the identification of compound 14a, which displays exceptional binding affinity for the D4 receptor (Ki = 0.3 nM) and remarkable selectivity over other dopamine receptor ...
Saeedeh Saeedi, Sumaiya Nahid, Anish Vadukoot, Corey R Hopkins   +3 more
wiley   +1 more source

Reversal of Chorea Hyperglycemia Basal Ganglia Syndrome With Glycemic Control: A Case Report. [PDF]

Clin Med Insights Case Rep
Gundraju S, Menda J, Suvvari TK, Pindi AK, Davala PK, Singh T, Thomas V.   +6 more
europepmc   +1 more source

Coordinate Network Mapping of Focal Brain Volume Differences in ADHD Reveals Common Patterns That Lack Specificity: A Systematic Review

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Attention‐deficit/hyperactivity disorder (ADHD) has been associated with decreased regional brain volume, yet no consistent localization has emerged across studies. This discrepancy has been attributed to ADHD's diagnostic heterogeneity; however, one alternative is that ADHD is associated with alterations of brain networks, not ...
Juliana Wall, Gillian N. Miller, Joseph J. Taylor, Jacob L. Stubbs, Simon K. Warfield, Alexander L. Cohen   +5 more
wiley   +1 more source

MRI findings in human rabies: A case report on the importance of neuroimaging when biological tests are inconclusive. [PDF]

Radiol Case Rep
Chahbi Z, Adnor S, Bigi S, Salek M, Wakrim S.   +4 more
europepmc   +1 more source

Aging and Color Vision: A Model Using the Farnsworth‐MUNSELL 100‐Hue Test

Color Research &Application, EarlyView.
ABSTRACT Introduction This study examined the theoretical changes in the FM100 Hue scores induced by age‐related changes in the ocular media transmittance. These changes were analyzed with and without a von Kries‐type chromatic adaptation to determine the role of this adaptation process on age‐related changes in hue discrimination.
Victor Opoku‐Yamoah, Stephen J. Dain, Jeffery K. Hovis   +2 more
wiley   +1 more source

Habitat analysis of iron deposition in the basal ganglia for diagnosing cognitive impairment in chronic kidney disease: evidence from a case-control study. [PDF]

BMC Med Imaging
Wang H, Qi Y, Liu X, Song LJ, Yang WB, Li MA, Bai XY, Xu MS, Zhu HN, Cai SQ, Wang Y, Yang ZH, Li YZ, Wang ZC, Guo YF.   +14 more
europepmc   +1 more source

Dynamic expression of lamin B1 during adult neurogenesis in the vertebrate brain

Developmental Dynamics, EarlyView.
Abstract Background In mammals, specific brain regions such as the dentate gyrus (DG) of the hippocampus and the subventricular zone (SVZ) of the lateral ventricles harbor adult neural stem/progenitor cells (ANSPCs) that give rise to new neurons and contribute to structural and functional brain plasticity.
Diana Zhilina, Lizbeth A. Bolaños Castro, Juan Sebastian Eguiguren, Sara Zocher, Anne Karasinsky, Dimitri Widmer, Alexandre Espinós, Victor Borrell, Michael Brand, Kyoko Miura, Oliver Zierau, Maximina H. Yun, Tomohisa Toda   +12 more
wiley   +1 more source

Impact of enlarged perivascular spaces in the basal ganglia on gait in cerebral small vessel disease. [PDF]

Aging Clin Exp Res
Yang S, Jiang J, Wang L, Zhao M, Li W, Duan Y, Ren Q, Jiang T, Jiang S, Zhang H, Wang Y, Chen W, Xu J.   +12 more
europepmc   +1 more source

GEO combined with quantitative protein trait loci identify causative proteins in hypertrophic cardiomyopathy

ESC Heart Failure, EarlyView.
Abstract Aims Hypertrophic cardiomyopathy (HCM) is a rare genetic heart disease characterized by a limited patient population and scarce research and treatment resources. This study aimed to identify HCM‐associated proteins by integrating cardiac tissue data from the Gene Expression Omnibus (GEO) database with the latest protein quantitative trait ...
Bo Li, Xu Zhao, Yan Ding, Yi Zhang
wiley   +1 more source