Results 111 to 120 of about 117,087 (348)

Optogenetics and deep brain stimulation neurotechnologies [PDF]

, 2015
Brain neural network is composed of densely packed, intricately wired neurons whose activity patterns ultimately give rise to every behavior, thought, or emotion that we experience. Over the past decade, a novel neurotechnique, optogenetics that combines
A Berndt, A Berndt, A Priori, AA Kuhn, AA Kuhn, AS Chuong, B Sauer, B Wingeier, BY Chow, BY Chow, C Bamann, D Luo, D Oesterhelt, D Oesterhelt, D Williams, ES Boyden, EY Uc, F Zhang, F Zhang, G Foffani, G Miesenbock, G Nagel, J Cavanaugh, J Mobley, J Volkmann, J Wells, J Wietek, JG Bernstein, JG Bernstein, JG Bernstein, JL Spudich, JL Spudich, JO Dostrovsky, JZ Tsien, L Bekar, L Madisen, LA Gunaydin, M Weinberger, M Weinberger, MC Rodriguez-Oroz, MJ Lehmkuhle, ML Welter, MM Doroudchi, O Yizhar, P Brown, P Silberstein, R Levy, R Levy, R Levy, R Waehler, S Zhao, TW Chen, VC Anderson, X Han, X Han, X Han, X Han, X Han, X Liu   +58 more
core   +2 more sources

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Motor recovery following capsular stroke [PDF]

, 1993
The functional anatomy of motor recovery was studied by assessing motor function quantitatively in 23 patients following capsular or striatocapsular stroke.
Danek, Adrian, Fries, Wolfgang, Hamburger, C., Scheidtmann, K.   +3 more
core   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Computational Analysis of LDDMM for Brain Mapping

Frontiers in Neuroscience, 2013
One goal of computational anatomy is to develop tools to accurately segment brain structures in healthy and diseased subjects. In this paper, we examine the performance and complexity of such segmentation in the framework of the large deformation ...
Can eCeritoglu, Xiaoying eTang, Margaret eChow, Darian eHadjiabadi, Damish eShah, Timothy eBrown, Muhammad H. Burhanullah, Huong eTrinh, John eHsu, Katarina A. Ament, Deana eCrocetti, Susumu eMori, Stewart H Mostofsky, Stewart H Mostofsky, Stewart H Mostofsky, Steven eYantis, Michael I Miller, Michael I Miller, Michael I Miller, J Tilak eRatnanather, J Tilak eRatnanather, J Tilak eRatnanather   +21 more
doaj   +1 more source

Modeling effect of GABAergic current in a basal ganglia computational model

, 2012
Electrical high frequency stimulation (HFS) of deep brain regions is a method shown to be clinically effective in different types of movement and neurological disorders.
Claussen, Jens Christian, Hofmann, Ulrich G., Moser, Andreas, Njap, Felix   +3 more
core   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Algal polysaccharides: new perspectives for the treatment of basal ganglia neurodegenerative diseases

Frontiers in Neuroanatomy
The objective of this review was to verify the therapeutic effect of polysaccharides derived from algae in neurodegenerative disease models involving the basal ganglia.
Alessandra Marinho Miranda Lucena, Alessandra Marinho Miranda Lucena, Eudes Euler de Souza Lucena, Sebastião Pacheco Duque Neto, Leonardo Thiago Duarte Barreto Nobre, Leonardo Thiago Duarte Barreto Nobre, Hugo Alexandre Oliveira Rocha, Rafael Barros Gomes Câmara, Rafael Barros Gomes Câmara   +8 more
doaj   +1 more source

The Neuropsychiatry of Hyperkinetic Movement Disorders: Insights from Neuroimaging into the Neural Circuit Bases of Dysfunction

Tremor and Other Hyperkinetic Movements, 2013
Background: Movement disorders, particularly those associated with basal ganglia disease, have a high rate of comorbid neuropsychiatric illness.Methods: We consider the pathophysiological basis of the comorbidity between movement disorders and ...
Bradleigh D. Hayhow, Islam K. Hassan, Jeffrey C. Looi, Francesco Gaillard, Dennis Velakoulis, Mark Walterfang   +5 more
doaj   +1 more source

Coupled non-parametric shape and moment-based inter-shape pose priors for multiple basal ganglia structure segmentation [PDF]

, 2009
This paper presents a new active contour-based, statistical method for simultaneous volumetric segmentation of multiple subcortical structures in the brain.
Cetin, Mujdat, Ekin, Ahmet, Ercil, Aytul, Erçil, Aytül, Soldea, Octavian, Unal, Gozde, Unay, Devrim, Uzunbas, Mustafa Gokhan, Uzunbaş, Mustafa Gökhan, Çetin, Müjdat, Ünal, Gözde, Ünay, Devrim   +11 more
core   +3 more sources