Results 151 to 160 of about 117,260 (330)

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
Transplantation of medial ganglionic eminence (MGE) interneuron progenitors into APP/PS1 cortices restored the slow oscillation characteristic of Alzheimer's disease. Donor cells survived, migrated, and matured into functional GABAergic interneurons, forming synaptic connections.
Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, Moustafa Algamal, Rebecca L. Gillani, Theodore J. Zwang, Douglas Richardson, Janice R. Naegele, Daniel Vogt, Ksenia V. Kastanenka   +16 more
wiley   +1 more source

Basal ganglia hypoactivity during grip force in drug naïve Parkinson's disease [PDF]

, 2010
Matthew B. Spraker, Janey Prodoehl, Daniel M. Corcos, Cynthia L. Comella, David E. Vaillancourt   +4 more
openalex   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Basal ganglia atrophy in prodromal Huntington's disease is detectable over one year using automated segmentation

, 2011
D.S. Adnan Majid, Adam R. Aron, Wesley K. Thompson, Sarah Sheldon, Samar Hamza, Diederick Stoffers, Dominic Holland, Jody Goldstein, Jody Corey‐Bloom, Anders M. Dale   +9 more
openalex   +1 more source

Imbalanced basal ganglia connectivity is associated with motor deficits and apathy in Huntington’s disease

, 2021
Akshay Nair, Adeel Razi, Sarah Gregory, Robb R. Rutledge, Geraint Rees, Sarah J. Tabrizi   +5 more
openalex   +1 more source

Behavior‐ and Cell Type‐Specific Cortico‐Striatal Decoupling in a Parkinson's Disease‐Like Mouse Model

Advanced Science, EarlyView.
Utilizing dual‐site fiber photometry, this study examines cortico‐striatal coupling with cell type resolution, identifying behavior‐ and cell type‐specific cortico striatal decoupling and its dopamine‐dependent mechanism in a Parkinson's disease mouse model.
Xu‐Ran Yao, Yang Liu, Wei‐Tong Zheng, Mao‐Qing Huang, Kai‐Wen He   +4 more
wiley   +1 more source

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

Free water as a potential mediator linking basal ganglia peri-vascular spaces to white matter hyperintensities in cerebral small vessel disease [PDF]

Weixing Feng, Xinjun Lei, Xinbin Wang, Shangcheng Xu, Zhihua Xu   +4 more
openalex   +1 more source

Crossed functional specialization between the basal ganglia and cerebellum during vocal emotion decoding: Insights from stroke and Parkinson’s disease [PDF]

, 2022
Marine Thomasson, Damien Benis, Philippe Voruz, Arnaud Saj̈, Marc Vérin, Frédéric Assal, Didier Grandjean, Julie Péron   +7 more
openalex   +1 more source

AN EXAMINATION OF CONCURRENT DISCRIMINATION LEARNING WITHIN INDIVIDUALS WITH PARKINSON’S DISEASE [PDF]

, 2013
The main focus of this research is to further understand memory formation by examining the role of the basal ganglia in learning. Broadly, this study examines how the basal ganglia may play a role in a task that has been associated with declarative ...
Tuladhar, Darshana
core   +1 more source