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Basal ganglia activation in Parkinson's disease
Parkinsonism & Related Disorders, 2006The objective of this study was to compare basal ganglia activation in patients with Parkinson's disease to that of healthy controls, using functional MRI (fMRI). Six mildly-affected patients, off antiparkinsonian medications for at least 12h, and seven age-matched controls performed a unilateral motor switching task during fMRI data acquisition. Clear
A. Wilman +3 more
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Dopamine and Basal Ganglia Diseases
Archives of Neurology, 1961In July 1957, at the First International Congress of Neurological Sciences in Brussels, J. N. Cumings summarized the state of our knowledge on the biochemistry of basal ganglia diseases in one sentence: "The biochemical pathologist has so far been of practical assistance to the clinical neurologist and to the patient in only one of the group of ...
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Mitochondrial defects in basal ganglia diseases
Current Opinion in Neurology, 1995Mitochondrial DNA mutations are important causes of movement disorders and are often associated with basal ganglia degeneration. Leigh's disease and a form of generalized dystonia are caused by mitochondrial DNA mutations. Recent biochemical and genetic evidence suggests that some cases of Parkinson's disease may be caused by oxidative phosphorylation ...
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Neurophysiology of basal ganglia diseases
2007Publisher Summary This chapter discusses the neurophysiology of basal ganglia diseases. The anatomical structures of the basal ganglia are connected to each other by a network of interconnections and the functional organization is based on the connections with thalamus and cortical territories.
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1984
There are various conditions in which involuntary movements develop and in which pathological changes are present in the basal ganglia. Some of these conditions, and especially paralysis agitans, have been the subject of intense study during the past two decades.
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There are various conditions in which involuntary movements develop and in which pathological changes are present in the basal ganglia. Some of these conditions, and especially paralysis agitans, have been the subject of intense study during the past two decades.
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Stereotactic microdialysis of the basal ganglia in Parkinson's disease
Journal of Neuroscience Methods, 2012Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an efficacious treatment in patients with advanced Parkinson's disease, yet the mechanisms of STN DBS are poorly understood. The aims of this study were to develop a useful method for studying neurotransmitter alterations during DBS and for the pharmacokinetics of L-dopa in brain tissue ...
Anita Kullman +4 more
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Depth perception in cerebellar and basal ganglia disease
Experimental Brain Research, 2006There is increasing evidence that the cerebellum and the basal ganglia serve not only a role in motor control but also in visual perception. Patients with Parkinson's disease (PD) as well as patients with cerebellar lesions exhibit impairments of vision that are not fully explained by ocular motor deficits. It is less clear to which extent these visual
Kristen A. Pickett +5 more
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Somatostatin is increased in the basal ganglia in Huntington disease
Annals of Neurology, 1983AbstractHuntington disease (HD) is an autosomal dominant hereditary disorder characterized by premature cell death, predominantly in the neostriatum. Decreased concentrations of several neurotransmitters and neuropeptides have been reported in the basal ganglia in Huntington disease.
Paul E. Cooper +6 more
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Basal ganglia discharge abnormalities in Parkinson’s disease
2006In the traditional model of the pathophysiology of parkinsonism, parkinsonian motor signs are viewed as the result of changes in discharge rates in the basal ganglia. However, not all experimental findings can be explained by rate changes alone, and changes in discharge patterns in these nuclei are increasingly emphasized as pathophysiologically ...
Mahlon R. DeLong, Thomas Wichmann
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Computational physiology of the basal ganglia in Parkinson’s disease
2010The normal activity of basal ganglia neurons is characterized by Poisson-like (random) firing patterns. Correlations between neurons of the same structure are weak or non-existent. By contrast, synchronous oscillations are commonly found in the basal ganglia of human patients and animal models of Parkinson's disease. The frequency of these oscillations
Shlomo Elias +4 more
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