Results 301 to 310 of about 117,087 (348)

Dopamine and Basal Ganglia Diseases

Archives of Neurology, 1961
In July 1957, at the First International Congress of Neurological Sciences in Brussels, J. N. Cumings summarized the state of our knowledge on the biochemistry of basal ganglia diseases in one sentence: "The biochemical pathologist has so far been of practical assistance to the clinical neurologist and to the patient in only one of the group of ...
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Basal ganglia calcification: ‘Fahr’s disease’

Practical Neurology
Brain calcification is often detected incidentally, but basal ganglia calcification has a wide differential diagnosis, including genetic and acquired causes. Primary familial brain calcification (PFBC) (formerly ‘Fahr’s disease’) refers to neurological disorders characterised by bilateral, symmetrical deposition of calcium ...
Francesca Magrinelli, Aaron Jesuthasan, Kailash P Bhatia, Amit Batla   +3 more
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Mitochondrial defects in basal ganglia diseases

Current Opinion in Neurology, 1995
Mitochondrial DNA mutations are important causes of movement disorders and are often associated with basal ganglia degeneration. Leigh's disease and a form of generalized dystonia are caused by mitochondrial DNA mutations. Recent biochemical and genetic evidence suggests that some cases of Parkinson's disease may be caused by oxidative phosphorylation ...
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Neurophysiology of basal ganglia diseases

2007
Publisher Summary This chapter discusses the neurophysiology of basal ganglia diseases. The anatomical structures of the basal ganglia are connected to each other by a network of interconnections and the functional organization is based on the connections with thalamus and cortical territories.
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Basal Ganglia Diseases

Abstract The concept of multiple memory systems is based on the foundational studies that have dissociated the roles of the basal ganglia and medial temporal lobe structures in memory. While it is increasingly appreciated that there are complex interactions between these systems, there is clear evidence for nondeclarative memory ...
Sephira G. Ryman, Kathleen L. Poston
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Basal Ganglia Disease And Depression

2004
Abstract Diseases of the basal ganglia are quintessential neuropsychiatric disorders, characterized by abnormal movements, cognitive impairment, and psychiatric symptoms and signs. Depression is common in these illnesses and may occur at presentation or during the course of the illness.
Anjan Chatterjee, Karen Marder
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Basal ganglia discharge abnormalities in Parkinson’s disease

2006
In the traditional model of the pathophysiology of parkinsonism, parkinsonian motor signs are viewed as the result of changes in discharge rates in the basal ganglia. However, not all experimental findings can be explained by rate changes alone, and changes in discharge patterns in these nuclei are increasingly emphasized as pathophysiologically ...
T, Wichmann, M R, DeLong
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ATROPHY OF BASAL GANGLIA IN PICK'S DISEASE

Archives of Neurology & Psychiatry, 1944
Although several observers in recent years have commented on the occurrence of changes in parts of the central nervous system other than the cerebral cortex in the condition of symmetric cortical atrophy first described by Pick, most workers continue to emphasize the cortical changes in their evaluation of the clinical signs and symptoms.
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Cortico–Basal Ganglia Circuit Function in Psychiatric Disease

Annual Review of Physiology, 2016
Circuit dysfunction models of psychiatric disease posit that pathological behavior results from abnormal patterns of electrical activity in specific cells and circuits in the brain. Many psychiatric disorders are associated with abnormal activity in the prefrontal cortex and in the basal ganglia, a set of subcortical nuclei implicated in cognitive and
Lisa A, Gunaydin, Anatol C, Kreitzer
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Pathophysiology of the basal ganglia in Parkinson's disease

Trends in Neurosciences, 2000
Insight into the organization of the basal ganglia in the normal, parkinsonian and L-dopa-induced dyskinesia states is critical for the development of newer and more effective therapies for Parkinson's disease. We believe that the basal ganglia can no longer be thought of as a unidirectional linear system that transfers information based solely on a ...
J A, Obeso, M C, Rodríguez-Oroz, M, Rodríguez, J L, Lanciego, J, Artieda, N, Gonzalo, C W, Olanow   +6 more
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