Results 81 to 90 of about 117,087 (348)

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Revisiting the Molecular Mechanism of Neurological Manifestations in Antiphospholipid Syndrome: Beyond Vascular Damage

Journal of Immunology Research, 2014
Antiphospholipid syndrome (APS) is a multiorgan disease often affecting the central nervous system (CNS). Typically, neurological manifestations of APS include thrombosis of cerebral vessels leading to stroke and requiring prompt initiation of treatment ...
M. Carecchio, R. Cantello, C. Comi
doaj   +1 more source

Ionic Mechanisms Underlying the Excitatory Effect of Orexin on Rat Subthalamic Nucleus Neurons

Frontiers in Cellular Neuroscience, 2019
Central orexinergic system deficiency results in cataplexy, a motor deficit characterized with a sudden loss of muscle tone, highlighting a direct modulatory role of orexin in motor control.
Guang-Ying Li, Qian-Xing Zhuang, Xiao-Yang Zhang, Jian-Jun Wang, Jing-Ning Zhu   +4 more
doaj   +1 more source

Striatal topographical organization: Bridging the gap between molecules, connectivity and behavior

European Journal of Histochemistry, 2021
The striatum represents the major hub of the basal ganglia, receiving projections from the entire cerebral cortex and it is assumed to play a key role in a wide array of complex behavioral tasks.
Gianpaolo Antonio Basile, Salvatore Bertino, Alessia Bramanti, Rosella Ciurleo, Giuseppe Pio Anastasi, Demetrio Milardi, Alberto Cacciola   +6 more
doaj   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

EXTENSIVE INTRACRANIAL CALCIFICATION WITH NEUROLOGICAL AND OPHTHALMOLOGICAL COMPLICATIONS IN A PATIENT WITH IDIOPATHIC HYPOPARATHYROIDISM: A CASE REPORT [PDF]

Journal of IMAB, 2018
Background: Idiopathic hypoparathyroidism is a rare endocrine disorder caused by the deficiency of parathyroid hormone. It typically has a progressive course and is characterized by accumulations of calcium deposits in the basal ganglia bilaterally.
Maya P. Danovska, Diana L. Marinova, Igor Mladenovski, Emilia M. Ovcharov, Vesela Ivancheva, Nachko Totsev, Lyubomir Tzankov   +6 more
doaj   +1 more source

Oculogyric Crisis as the First Presentation of Biotin-Thiamine-Responsive Basal Ganglia Disease: A Case Report [PDF]

, 2023
Abdullah Nasser Aldosari
openalex   +1 more source

Biotin-responsive basal ganglia disease: a novel entity [PDF]

Brain, 1998
We describe a novel, biotin-responsive basal ganglia disease in 10 patients. At onset, it appears as a subacute encephalopathy, with confusion, dysarthria and dysphagia with occasional supranuclear facial nerve palsy or external ophthalmoplegia, and progresses to severe cogwheel rigidity, dystonia and quadriparesis.
P T, Ozand, G G, Gascon, M, Al Essa, S, Joshi, E, Al Jishi, S, Bakheet, J, Al Watban, M Z, Al-Kawi, O, Dabbagh   +8 more
openaire   +2 more sources

Karak syndrome: a novel degenerative disorder of the basal ganglia and cerebellum [PDF]

, 2003
Two brothers are reported with early onset progressive cerebellar ataxia, dystonia, spasticity, and intellectual decline. • Neuroradiology showed cerebellar atrophy and features compatible with iron deposition in the putamen (including the “eye of ...
Dheyyat, M., Din, A., Hampshire, D., Jamil, A., Kurdi, A., Mubaidin, A., Mubaidin, M., Roberts, E., Shurbaji, A., Woods, C.G.   +9 more
core   +2 more sources

Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Abnormalities on peri‐ictal diffusion‐weighted magnetic resonance imaging (DWI‐PMAs) are well‐established for patients with status epilepticus (SE), but knowledge on patterns of DWI‐PMAs and their prognostic impact is sparse. Methods This systematic review and individual participant data meta‐analysis included observational studies ...
Andrea Enerstad Bolle, Silvana Sarria‐Estrada, Thomas Bonduelle, Bertram Daniel Dynesen, Manuel Toledo, Zhu Chung Che, Kjell Heuser, Anastasios Chatzikonstantinou, Jérôme Aupy, Udaya Seneviratne, Estevo Santamarina Perez, Christoph Patrick Beier   +11 more
wiley   +1 more source