Results 201 to 210 of about 75,758 (252)

A Rare CTBP1-Related Neurodevelopmental Disorder Is Associated with Impaired Mitochondrial Bioenergetics: A Functional Case Report. [PDF]

Int J Mol Sci
Ivanov Z, Gevezova M, Pacheva I, Ketev K, Chochkova-Bukova L, Sarafian V, Ivanov I.   +6 more
europepmc   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Short-Chain Fatty Acids and Palmitate Induce Distinct Metabolic and Phenotypic Signatures in Normal and Ischemic Skeletal Muscle Microvascular Endothelial Cells. [PDF]

Cells
Guilfoyle-Speese A, Patel K, Ghanwat AH, Stepp D, Ganta V.   +4 more
europepmc   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Characterization of a <i>UQCRC1</i> variant in a patient with progressive weakness, pain and sleep issues reveals a functional mitochondrial defect restored by mitochondrial transplantation. [PDF]

Mol Genet Metab Rep
Piroli GG, Myers R, Holloway L, Hayek A, Linebaugh E, Jones JR, Skinner C, Skinner SA, Frizzell N, Steet R.   +9 more
europepmc   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Correction: Kovacevic et al. The Effect of Deoxycholic Acid on Chitosan-Enabled Matrices for Tissue Scaffolding and Injectable Nanogels. <i>Gels</i> 2022, <i>8</i>, 358. [PDF]

Gels
Kovacevic B, Ionescu CM, Jones M, Wagle SR, Lewkowicz M, Đanić M, Mikov M, Mooranian A, Al-Salami H.   +8 more
europepmc   +1 more source

Adiponectin modulates the diurnal hepatic transcriptome and energy metabolism in male mice. [PDF]

Endocr Connect
Hirose M, Calvo E, Pilorz V, Kaehler M, Cascorbi I, Nagel I, de Assis LVM, Oster H.   +7 more
europepmc   +1 more source

1,1-Diethoxyethane enhances aerobic respiration in human mitochondria via activation of AMP-activated protein kinase. [PDF]

Commun Biol
Nguyen Huu T, Duong Thanh H, Kim MK, Kumar Sah D, Trinh VH, Yoon HJ, Choi JM, Lee GH, Kim SY, Lee SR.   +9 more
europepmc   +1 more source

Ethylmalonic and Methylsuccinic Acids Disrupt Bioenergetics and Induce Mitochondrial Permeability Transition Through Thiol Redox Modulation in Rat Striatum: Potential Mechanisms Involved in Ethylmalonic Encephalopathy. [PDF]

Neurochem Res
Marcuzzo MB, Zemniaçak ÂB, da Rosa JS, Verdi BSS, Benati MPDV, de Andrade Silveira J, do Nascimento JG, de Almeida Moreira H, Dias-Oliveira M, Souza DO, Amaral AU, Zanatta G, Wajner M, Leipnitz G.   +13 more
europepmc   +1 more source