Results 61 to 70 of about 75,758 (252)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Aerobic capacity and mitochondrial function in bipolar disorder: a longitudinal study during acute phases and after clinical remission

Frontiers in Psychiatry
BackgroundAerobic capacity has shown to predict physical and mental health-related quality of life in bipolar disorder (BD). However, the correlation between exercise respiratory capacity and mitochondrial function remains understudied.
Anna Giménez-Palomo, Anna Giménez-Palomo, Anna Giménez-Palomo, Anna Giménez-Palomo, Mariona Guitart-Mampel, Gemma Roqué, Ester Sánchez, Roger Borràs, Roger Borràs, Ana Meseguer, Francesc Josep García-García, Esther Tobías, Laura Valls-Roca, Gerard Anmella, Gerard Anmella, Gerard Anmella, Gerard Anmella, Marc Valentí, Marc Valentí, Marc Valentí, Marc Valentí, Luis Olivier, Luis Olivier, Luis Olivier, Luis Olivier, Oscar de Juan, Oscar de Juan, Oscar de Juan, Oscar de Juan, Iñaki Ochandiano, Iñaki Ochandiano, Iñaki Ochandiano, Iñaki Ochandiano, Helena Andreu, Helena Andreu, Helena Andreu, Helena Andreu, Joaquim Radua, Joaquim Radua, Joaquim Radua, Joaquim Radua, Norma Verdolini, Michael Berk, Michael Berk, Eduard Vieta, Eduard Vieta, Eduard Vieta, Eduard Vieta, Glòria Garrabou, Josep Roca, Xavier Alsina-Restoy, Isabella Pacchiarotti, Isabella Pacchiarotti, Isabella Pacchiarotti, Isabella Pacchiarotti   +54 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Atributos biológicos indicadores da qualidade do solo em pastagem cultivada e nativa no Pantanal Biological indicator attributes of soil quality under cultivated and natural pasture in the Pantanal wetlands

Pesquisa Agropecuária Brasileira, 2009
O objetivo deste trabalho foi avaliar as alterações nos atributos biológicos do solo, em razão da conversão floresta nativa pastagem cultivada e submissão de pastagens nativas a sistema pastejo contínuo, um Neossolo Quartzarênico, no Pantanal sul-mato ...
Evaldo Luis Cardoso, Marx Leandro Naves Silva, Fátima Maria de Souza Moreira, Nilton Curi   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Mineralização do carbono orgânico em solos tratados com lodo de curtume Mineralization of the organic carbon in soils treated with tannery sludges

Pesquisa Agropecuária Brasileira, 2006
O objetivo deste trabalho foi avaliar a mineralização do carbono orgânico do lodo de curtume, aplicado em solos com diferentes classes texturais, de modo a caracterizar a cinética do processo de mineralização e auxiliar na elaboração de normas técnicas ...
Alexandre Martin Martines, Cristiano Alberto de Andrade, Elke Jurandy Bran Nogueira Cardoso   +2 more
doaj   +1 more source

Basal soil respiration under different service plant mulches

Brazilian Journal of Animal and Environmental Research
Soil microbial activity is strongly influenced by agricultural management and the quality of plant residues added to the system. Basal soil respiration is an important biological indicator, as it expresses the CO₂ emissions resulting from the decomposition of organic matter by microorganisms.
Arthur Bredow Neubauer, Nicole Bulsing Lemes, Yohan Daniel Silva Jorge, Benjamin Dias Osório Filho   +3 more
openaire   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

SituResp®: A time- and cost-effective method to assess basal soil respiration in the field

Applied Soil Ecology, 2017
Abstract The soil microbial activity is a key parameter in numerous studies aiming to assess soil quality in agricultural plots. Basal Soil Respiration (BSR) has been extensively used as an indicator of this soil microbial activity. However, available methods to measure BSR remain time- and labor- consuming and must be performed in the laboratory ...
Thoumazeau, Alexis, Gay, Frédéric, Alonso, Pascal, Suvannange, Nopmanee, Phongjinda, Audjima, Panklang, Phantip, Chevallier, Tiphaine, Bessou, Cécile, Brauman, Alain   +8 more
openaire   +5 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source