Results 91 to 100 of about 13,683 (246)

Model‐Informed Drug Development‐Based Bridging from Subcutaneous to Intravenous Secukinumab Dosing: Approval in Psoriatic Arthritis and Axial Spondyloarthritis

Clinical Pharmacology &Therapeutics, Volume 118, Issue 2, Page 480-488, August 2025.
The objective of this modeling and simulation analysis was to determine an intravenous (IV) secukinumab dosing regimen with steady‐state exposure within the ranges of the approved subcutaneous (SC) regimens (300 and 150 mg every 4 weeks [q4w]) and to predict the efficacy and safety of this IV regimen for patients with psoriatic arthritis (PsA) or axial
Thomas Dumortier, Guillermo Valenzuela, Melvin Churchill, Jelena Mijatovic, Gerard Bruin, Luminita Pricop, Hanno Richards, Didier Renard, Atul Singhal, Anshu Marathe   +9 more
wiley   +1 more source

Improvement in pain intensity, spine stiffness, and mobility during a controlled individualized physiotherapy program in ankylosing spondylitis [PDF]

, 2011
Physical therapy in ankylosing spondylitis (AS) is important for maintaining or improving mobility, fitness, functioning, and global health. It also plays a role in the prevention and management of structural deformities.
András, Anita, Bodnár, Nóra, Némethné Gyurcsik, Zsuzsanna, Szekanecz, Zoltán, Szántó, Sándor Zoltán   +4 more
core   +1 more source

Sex‐Related Differences in Efficacy and Safety Outcomes in Axial Spondyloarthritis Randomized Clinical Trials: A Systematic Literature Review and Meta‐Analysis

Arthritis Care &Research, Volume 77, Issue 7, Page 813-826, July 2025.
Objective We aimed to assess differences in baseline characteristics, efficacy, and safety of advanced therapies between male and female patients with axial spondyloarthritis (axSpA) in randomized controlled trials (RCTs). Methods We conducted a systematic literature search for RCTs assessing the efficacy of advanced therapies in patients with axSpA ...
Angel Gao, Jordi Pardo Pardo, Steven Dang, Lianne S. Gensler, Philip Mease, Lihi Eder   +5 more
wiley   +1 more source

BioRePortAP, an electronic clinical record coupled with a database : an example of its use in a single [PDF]

, 2010
Aims: To evaluate the efficacy and safety of the treatment of psoriatic arthritis (PsA) patients with tumor necrosis factor (TNF) antagonists in the Rheumatology Department of Hospital de Santa Maria using the BioRePortAP.
Campanilho-Marques, R., Canhao, Helena, Costa, M., Fonseca, João Eurico, Martins, F., Pereira da Silva, José A., Polido-Pereira, J., Ramos, F., Rodrigues, A., Saavedra, M. J.   +9 more
core  

results from the German Spondyloarthritis Inception Cohort [PDF]

, 2017
Background Functional status and spinal mobility in patients with axial spondyloarthritis (axSpA) are known to be determined both by disease activity and by structural damage in the spine. The impact of structural damage in the sacroiliac joints (SIJ) on
Haibel, Hildrun, Listing, Joachim, Poddubnyy, Denis, Protopopov, Mikhail, Rudwaleit, Martin, Sieper, Joachim   +5 more
core   +1 more source

An Immunosenescent CD8+ T Cell Subset in Patients with Axial Spondyloarthritis and Psoriatic Arthritis Links Spontaneous Motility to Telomere Shortening and Dysfunction

Arthritis &Rheumatology, Volume 77, Issue 7, Page 854-866, July 2025.
Objective A pathogenetic role of CD8+ T lymphocytes in radiographic axial spondyloarthritis (r‐axSpA) and other spondyloarthritis (SpA) is sustained by genome‐wide association studies and by the expansion of public T cell clonotypes in the target tissues.
Giorgia Paldino, Valentina Tedeschi, Valentina Proganò, Erica Salvati, Valerio Licursi, Eleonora Vertecchi, Alexandru L. Bivolaru, Emanuele Molteni, Rossana Scrivo, Mattia Congia, Alberto Cauli, Rosalba Caccavale, Marino Paroli, Martina Kunkl, Loretta Tuosto, Rosa Sorrentino, Maria Teresa Fiorillo   +16 more
wiley   +1 more source

A 2-year comparative open label randomized study of efficacy and safety of etanercept and infliximab in patients with ankylosing spondylitis [PDF]

, 2010
The signs and symptoms of ankylosing spondylitis (AS) respond inadequately to nonsteroidal antiinflammatory drugs, corticosteroids, and disease modifying antirheumatic drugs in quite a number of patients.
Ciccia, F., Ferrante, A., Giardina, A., Impastato, R., Miceli, M., Principato, A., Triolo, G.   +6 more
core   +1 more source

Efficacy and safety of upadacitinib in patients with active psoriatic arthritis and axial involvement: results from two phase 3 studies

Arthritis Research & Therapy, 2023
Background The objective of this post-hoc analysis was to assess the efficacy and safety of upadacitinib in psoriatic arthritis (PsA) patients with axial involvement.
Xenofon Baraliakos, Roberto Ranza, Andrew Östör, Francesco Ciccia, Laura C. Coates, Simona Rednic, Jessica A. Walsh, Kevin Douglas, Tianming Gao, Koji Kato, In-Ho Song, Fabiana Ganz, Atul Deodhar   +12 more
doaj   +1 more source

A Review of Ankylosing Spondylitis [PDF]

, 2017
Ankylosing spondylitis (AS) is a systemic autoimmune disorder that induces ankylosis of the spine (fusion of the vertebrae at their various joints) and inflammatory arthritis of peripheral joints among other symptoms.
Owen, Hannah L
core   +1 more source

Increasing smoking intensity is associated with increased disease activity in axial spondyloarthritis. [PDF]

, 2016
A history of ever-smoking appears to be associated with a more severe disease phenotype in axial spondyloarthritis (axSpA). However, evidence is sparse for the effect of increased smoking exposure on disease outcomes or whether smoking reduction or ...
Challoner, B, Goodson, NJ, Khattak, M, Moots, RJ, Zhao, S   +4 more
core   +1 more source