Results 111 to 120 of about 773,476 (276)

Expanding the CRISPR base editing toolbox in Drosophila melanogaster

open access: yesCommunications Biology
CRISPR base editors can introduce point mutations into DNA precisely, and cytosine base editors (CBEs) catalyze C to T transitions. While CBEs have been thoroughly explored in cell culture and organisms such as mice, little is known about DNA base ...
Michael Clark   +6 more
doaj   +1 more source

Students With Disabilities and California's Special Education Program [PDF]

open access: yes, 2009
Provides an overview of the state's special education programs, including eligibility, enrollment, student performance, time spent outside regular classrooms, spending, and financing, compared to national trends.
Stephen Lipscomb
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

How could a rational analysis model explain? [PDF]

open access: yes, 2017
Rational analysis is an influential but contested account of how probabilistic modeling can be used to construct non-mechanistic but self-standing explanatory models of the mind.
Reijula, Samuli
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Review Based Rating Prediction

open access: yes, 2016
Recommendation systems are an important units in today's e-commerce applications, such as targeted advertising, personalized marketing and information retrieval. In recent years, the importance of contextual information has motivated generation of personalized recommendations according to the available contextual information of users.
openaire   +2 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Pediatric Developmental Screening: Understanding and Selecting Screening Instruments [PDF]

open access: yes, 2008
Based on a review of research on developmental screening instruments, provides a manual for selecting and applying tools for screening for both general and specific problems.
Dennis Drotar   +2 more
core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

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