Results 121 to 130 of about 773,476 (276)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Voice recognition enhancement by genetic algorithm

Heliyon
This research paper investigates the application of Genetic Algorithms (GA) in optimizing Artificial Neural Networks (ANN) for phoneme recognition.
Mohamed Salah Salhi, Ali Hamdan Alenezi
doaj   +1 more source

The True Cost of Boston's Charter Schools: Charter Expansion Has Not Been a Revenue Issue for Boston Public Schools [PDF]

, 2016
As Boston approaches its cap on charter schools seats, and long wait lists remain at many of the Commonwealth charter schools serving Boston residents, efforts have begun to lift the charter cap and expand the number of seats available to Boston ...

core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The key role of base rates: systematic review and meta-analysis of the predictive value of four risk assessment instruments

Swiss Medical Weekly
AIMS OF THE STUDY: Many countries have seen a decline in recidivism rates over the past decades. These base rates are pertinent information for assessing the recidivism risk of offenders.
Michael A. Weber, Nina Schnyder, Madeleine A. Kirschstein, Marc Graf, Jérôme Endrass, Astrid Rossegger   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

When one graph judgment leads to another: Signal detection analysis of base rate effects

Judgment and Decision Making
Graphs can help people arrive at data-supported conclusions. However, graphs might also induce bias by shifting the amount of evidence needed to make a decision, such as deciding whether a treatment had some kind of effect.
Ethan C. Guthrie, Anthony J. Bishara
doaj   +1 more source

Actuarial Impacts of Loss Cost Ratio Ratemaking in U.S. Crop Insurance Programs [PDF]

This study examines the actuarial implications of the loss cost ratio (LCR) ratemaking methodology employed by the Risk Management Agency as a component of base rates for U.S.
Schnitkey, Gary D., Sherrick, Bruce J., Woodard, Joshua D.   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source