Results 201 to 210 of about 2,385,323 (336)

Dual-energy X-ray absorptiometry–based body volume measurement for 4-compartment body composition [PDF]

, 2011
Joseph Wilson, Kathleen Mulligan, Bo Fan, Jennifer Sherman, Elizabeth J. Murphy, Viva Tai, Cassidy Powers, Lorena Marquez, Viviana Ruiz-Barros, John Shepherd   +9 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

On the genome base composition of teleosts: the effect of environment and lifestyle. [PDF]

BMC Genomics, 2016
Tarallo A, Angelini C, Sanges R, Yagi M, Agnisola C, D'Onofrio G.   +5 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Large scale variation in the rate of germ-line de novo mutation, base composition, divergence and diversity in humans. [PDF]

PLoS Genet, 2018
Smith TCA, Arndt PF, Eyre-Walker A.
europepmc   +1 more source

Biological integrity of the East Boulder River based on the composition and structure of the Benthic algae community

, 2001
Loren L. Bahls, Montana.
openalex   +2 more sources

Compositional abstraction-based synthesis for continuous-time stochastic hybrid systems

, 2020
Ameneh Nejati, Sadegh Soudjani, Majid Zamani   +2 more
openalex   +2 more sources

Body Composition Prediction—BOMP: Validity Assessment of an Artificial Neural Networks-Based Tool for Assessing Fat and Lean Body Mass

, 2023
Irismar Gonçalves Almeida da Encarnação, Matheus Santos Cerqueira, Simon Lebech Cichosz, Cláudia Eliza Patrocínio de Oliveira, João Carlos Bouzas Marins, Osvaldo Costa Moreira   +5 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source