Results 91 to 100 of about 4,964,317 (260)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Design of Base Isolation System for Buildings
, 2018 Seismic base isolation is one of the most widely implemented and accepted seismic protection systems and is a relatively recent and evolving technology. The most common isolation system used is Laminated Lead Rubber Bearings (LLRB).
Govardhan Bhatt +2 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Design Of A Miniature Base Isolation Demo
, 2023 In this project, we will design a miniature base isolation demo. The objective is to design the total mass, stiffness, and damping (mb, kb, cb) of a base isolation system for a single-story building, subject to the design spectrum described below.
Baishya, Ronit +2 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
PEMBUATAN BENDA UJI BASE-ISOLATION UNTUK RUMAH SEDERHANA TAHAN GEMPA [PDF]
, 2018 Banyak cara yang dapat dilakukan untuk meredam getaran yang ditimbulkan gempa pada struktur, salah satunya adalah dengan menggunakan base isolation yang terletak antara struktur bawah dan atas.
Widhiyanti, Susy +2 more
core
RECENT APPLICATIONS OF SEISMIC ISOLATION IN ITALY
, 2019 This paper presents a state-of-the-art on seismic isolation in Italy and the most important applications. Those to new strategic and public buildings are shown, as well as to new residential buildings, pointing out the very good behavior shown by the ...
Martelli, A. +3 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
BuildingsBase isolation technology, as a mature seismic mitigation method, demonstrates potential for enhancing seismic margins in nuclear power plant structures.
Yunhui Xiao +3 more
doaj +1 more source