Results 71 to 80 of about 434,138 (268)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
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Isolation-Based Debugging for Neural Networks
Proceedings of the 33rd ACM SIGSOFT International Symposium on Software Testing and AnalysisNeural networks (NNs) are known to have diverse defects such as adversarial examples, backdoor and discrimination, raising great concerns for their reliability. While NN testing can effectively expose these problems to a significant degree, their root cause in the network is subject to further examination.
Jialuo Chen +4 more
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FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
AN INVESTIGATION OF BASE ISOLATION
Selçuk Üniversitesi Mühendislik, Bilim ve Teknoloji Dergisi, 2012 The effect of weak shear rigidity is important in the analysis of elastomeric bearings used for base isolation of buildings. In particular, the buckling load is low and the P-Δ effect is significant as compared to standard columns neglecting shear deformations. In this paper, a simple mechanical model accounting for both shear and flexural deformations
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FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
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Applied SciencesThe mutual interaction between base isolation (BI) and soil–structure interaction (SSI) needs to be considered in design applications. In the literature, the key parameters that may affect such interaction have been rarely considered. Closed formulations
Davide Forcellini
doaj +1 more source
Applicability of base isolation made of elastomeric isolators for the protection of cultural heritage [PDF]
Urbani Izziv, 2009 This article briefly presents the applicability of base isolation made of elastomeric isolators for the protection of heritage architecture. The first part of the article gives an illustrative overview on the use of base isolation throughout the world ...
Vojko Kilar +2 more
doaj
Bulletin of the New Zealand Society for Earthquake Engineering, 1983 International conference in Kuala Lumpur, Malaysia, 22-25 February ...
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source