Results 61 to 70 of about 4,964,317 (260)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Application of Machine Learning for Predicting Seismic Damage in Base-Isolated Reinforced Concrete Buildings

CivilEng
Base isolation is known as a useful and popular technique for seismic upgrading of reinforced concrete buildings. Predicting damage levels based on relative inter-story drift plays an important role for designing optimal base isolation systems.
Mohamed Algamati, Abobakr Al-Sakkaf, Ashutosh Bagchi   +2 more
doaj   +1 more source

COMPARATIVE STUDY REGARDING THE NON-ISOLATED CIRCULAR ABOVE-GROUND PARKING LOT AND THE PARKING LOT ISOLATED BY MEANS OF THE BASE ISOLATION METHOD [PDF]

Journal of Research and Innovation for Sustainable Society, 2020
This paper studies the beneficial effects of the base isolation method. "The design/consolidation method by base isolation" consists in increasing the fundamental vibration period, decreasing displacement.
Edward RĂȘCHITOR, Carmen Elisabeta RADU, Violeta Elena ȘTEFĂNESCU, Iosif TEMPEA   +3 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Evaluation of the dynamic response of structures using auxetic-type base isolation

Fracture and Structural Integrity, 2020
Base isolation is a widely-used method used to minimise the harmful effects of earthquakes on buildings. Unlike a fixed base building, a building with a base isolation system essentially decouples the superstructure from the substructure resting on the ...
Georgios Drosopoulos, Preyolin Naidoo
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Advancing seismic performance: Isolators, TMDs, and multi-level strategies in reinforced concrete buildings

Open Engineering
This study evaluates seismic mitigation methods, including high damping rubber bearing, lead rubber bearing, double sliding pendulum (DSP), and tuned mass damper (TMD), considering earthquake intensity, building height, and isolation level. Moreover, the
Jasim Fadhil A., Jasim Nabeel A., Al-Hussein Abdullah A.   +2 more
doaj   +1 more source

Metaheuristics-Based Optimization of a Control System Consisting of Underground Tuned Mass Dampers and Base Isolators for Seismic Structures

GeoHazards
To reduce earthquake damage and its effect on the structures, tuned mass dampers (TMDs) are generally positioned on the top of the structures for effectiveness, but existing TMDs on the story levels have problems due to space and additional vertical load
Farnaz Ahadian, Gebrail Bekdaş, Sinan Melih Nigdeli, Sanghun Kim, Zong Woo Geem   +4 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source