Results 61 to 70 of about 434,138 (268)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

K-Means-based isolation forest

Knowledge-Based Systems, 2020
Abstract The task of anomaly detection in data is one of the main challenges in data science because of the wide plethora of applications and despite a spectrum of available methods. Unfortunately, many of anomaly detection schemes are still imperfect i.e., they are not effective enough or act in a non-intuitive way or they are focused on a specific ...
Pawel Karczmarek, Adam Kiersztyn, Witold Pedrycz, Ebru Al   +3 more
openaire   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Advancing seismic performance: Isolators, TMDs, and multi-level strategies in reinforced concrete buildings

Open Engineering
This study evaluates seismic mitigation methods, including high damping rubber bearing, lead rubber bearing, double sliding pendulum (DSP), and tuned mass damper (TMD), considering earthquake intensity, building height, and isolation level. Moreover, the
Jasim Fadhil A., Jasim Nabeel A., Al-Hussein Abdullah A.   +2 more
doaj   +1 more source

Metaheuristics-Based Optimization of a Control System Consisting of Underground Tuned Mass Dampers and Base Isolators for Seismic Structures

GeoHazards
To reduce earthquake damage and its effect on the structures, tuned mass dampers (TMDs) are generally positioned on the top of the structures for effectiveness, but existing TMDs on the story levels have problems due to space and additional vertical load
Farnaz Ahadian, Gebrail Bekdaş, Sinan Melih Nigdeli, Sanghun Kim, Zong Woo Geem   +4 more
doaj   +1 more source

Enhancing Friction Pendulum Isolation Systems Using Passive and Semi-Active Dampers

Applied Sciences, 2020
Friction pendulum systems (FPSs) are a common solution for isolating civil engineering structures under ground movements. The result is a base-isolated structure in which the base exhibits low shear stiffness in such a way that the input energy of the ...
Christian A. Barrera-Vargas, Iván M. Díaz, José M. Soria, Jaime H. García-Palacios   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Hybrid Passive Control Strategies for Reducing the Displacements at the Base of Seismic Isolated Structures

Frontiers in Built Environment, 2019
In this paper, the use of hybrid passive control strategies to mitigate the seismic response of a base-isolated structure is examined. The control performance of three different types of devices used for reducing base displacements of isolated buildings ...
Alberto Di Matteo, Chiara Masnata, Antonina Pirrotta, Antonina Pirrotta   +3 more
doaj   +1 more source