Results 51 to 60 of about 1,859,090 (336)

Sequence-specific double-strand cleavage of DNA by penta-N-methylpyrrolecarboxamide-EDTA·Fe(II) [PDF]

, 1983
In the presence of O2 and 5 mM dithiothreitol, penta-N-methylpyrrolecarboxamide-EDTA·Fe(II) [P5E·Fe(II)] at 0.5 µ M cleaves pBR322 plasmid DNA (50 µ M in base pairs) on opposite strands to afford discrete DNA fragments as analyzed by agarose gel ...
Dervan, Peter B., Schultz, Peter G.
core  

Self-organised criticality in base-pair breathing in DNA with a defect

, 2011
We analyse base-pair breathing in a DNA sequence of 12 base-pairs with a defective base at its centre. We use both all-atom molecular dynamics (MD) simulations and a system of stochastic differential equations (SDE).
Ambjörnsson, Bak, Bak, Bak, Bak, Cadoni, Caldarelli, Chapman, Charles A. Laughton, Chopard, Ciprian-Ionuţ Duduială, Cubero, Drossel, Duduială, Gaeta, Guckian, Haken, Harris, Hennig, Jonathan A.D. Wattis, Newman, Olami, Peng, Peyrard, Peyrard, Peyrard, Peyrard, Phillips, Phillips, Ruelle, Schlitter, Watson, Wattis, Wattis, Werner, Wolfram, Zinn-Justin   +36 more
core   +1 more source

Implementing Health‐Related Quality of Life Assessment in Pediatric Oncology: A Feasibility Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background There is growing interest in embedding health‐related quality of life (HRQoL) assessment and patient‐reported outcome measures (PROMs) within clinical cancer care. This study evaluated the feasibility, acceptability, and usability of implementing an electronic PROM (ePROM) platform to measure HRQoL in children with cancer ...
Mikaela Doig, Sophie Jessop, Jordan R. Hansford, Hien Le, Matthew O'Connor, Peter Gorayski, Andrew Cunningham, Amanda Hutchinson, Victoria Bedford, Eva Bezak, Nayana Parange, Kelly Skelton, Timothy Price, Michala Short   +13 more
wiley   +1 more source

Aviram-Ratner rectifying mechanism for DNA base pair sequencing through graphene nanogaps

, 2012
We demonstrate that biological molecules such as Watson-Crick DNA base pairs can behave as biological Aviram-Ratner electrical rectifiers because of the spatial separation and weak hydrogen bonding between the nucleobases.
Christian Wolowiec, Endres R G Cox D L Singh R R P, Jacob Gayles, Luis A Agapito, Nicholas Kioussis, Riahi S, Soler J M   +6 more
core   +1 more source

Treatment Decision‐Making Roles and Preferences Among Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Decision‐making (DM) dynamics between adolescents and young adults (AYAs) with cancer, parents, and oncologists remain underexplored in diverse populations. We examined cancer treatment DM preferences among an ethnically and socioeconomically diverse group of AYAs and their parents.
Amanda M. Gutierrez, Jill O. Robinson, Wendy A. Allen‐Rhoades, Hadley S. Smith, Isabel Canfield, Rebecca L. Hsu, Sarah R. Scollon, Lauren R. Desrosiers‐Battu, Nicole M. Schneider, Frank Y. Lin, Donald Williams Parsons, Sharon E. Plon, Mary A. Majumder, Janet Malek, Amy L. McGuire   +14 more
wiley   +1 more source

A Mathematical Model for RNA 3D Structures

Mathematics
The computational prediction of RNA three-dimensional (3D) structures remains a significant challenge, largely due to the limited understanding of RNA folding pathways.
Sixiang Zhang, Liming Cai
doaj   +1 more source

Modeling DNA Structure, Elasticity and Deformations at the Base-pair Level

, 2003
We present a generic model for DNA at the base-pair level. We use a variant of the Gay-Berne potential to represent the stacking energy between neighboring base-pairs.
A. Sarkar, B. Essevaz-Roulet, Boris Mergell, C. Bustamante, C. O’Hern, C.A. Hunter, C.A. Hunter, C.F. Guerra, C.R. Calladine, D. Bensimon, D.P. Millar, G. Chirico, G. Wedemann, H. Schiessel, I. Lafontaine, I. Rouzina, I. Rouzina, J. Allemand, J. Bednar, J.D. Watson, J.F. Marko, J.F. Marko, J.F. Marko, J.G. Gay, J.M. Schurr, M. Barbi, M. Vologodskaia, M.A.E. Hassan, M.A.E. Hassan, M.C. Williams, M.J. Packer, M.S. Babcock, Mohammad R. Ejtehadi, N. Bruant, N. Metropolis, P. Cluzel, P. Nelson, R. Everaers, R. Lavery, R. Lavery, R. Podgornik, R.D. Kamien, R.E. Dickerson, R.E. Dickerson, R.E. Dickerson, Ralf Everaers, S. Cocco, S.B. Smith, S.B. Smith, T. Odijk, T. Schlick, T.C. Boles, T.L. James, T.R. Strick, T.R. Strick, T.T. Perkins, T.T. Perkins, U. Bockelmann, V. Katritch, W.K. Olson, X.J. Lu, Y. Fang, Z. Haijun   +62 more
core   +1 more source

Parent Quality of Life at Two Years Following Their Child's Completion of Acute Lymphoblastic Leukemia Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Parents of children treated for acute lymphoblastic leukemia (ALL) often experience significant caregiver burden and disruption to their well‐being. While parent quality of life (QoL) during treatment is well characterized, little is known about outcomes during early survivorship.
Sara Dal Pra, Maria McCarthy, Michael Takagi, Cinzia De Luca   +3 more
wiley   +1 more source

Sequence dependency of canonical base pair opening in the DNA double helix. [PDF]

PLoS Computational Biology, 2017
The flipping-out of a DNA base from the double helical structure is a key step of many cellular processes, such as DNA replication, modification and repair.
Viveca Lindahl, Alessandra Villa, Berk Hess   +2 more
doaj   +1 more source

Insights into the Structures of DNA Damaged by Hydroxyl Radical: Crystal Structures of DNA Duplexes Containing 5-Formyluracil

Journal of Nucleic Acids, 2010
Hydroxyl radicals are potent mutagens that attack DNA to form various base and ribose derivatives. One of the major damaged thymine derivatives is 5-formyluracil (fU), which induces pyrimidine transition during replication.
Masaru Tsunoda, Takeshi Sakaue, Satoko Naito, Tomoko Sunami, Naoko Abe, Yoshihito Ueno, Akira Matsuda, Akio Takénaka   +7 more
doaj   +1 more source