Results 51 to 60 of about 30,427,296 (288)
BMC Biotechnology, 2021 Background The use of CRISPR/Cas9 technologies in generating single-base pair knock-in mutations has recently exploded in the number of methods available.
Carina Edmondson, Qi Zhou, Xuan Liu
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Influence of a fluorobenzene nucleobase analogue on the conformational flexibility of RNA studied by molecular dynamics simulations [PDF]
, 2006 Chemically modified bases are frequently used to stabilize nucleic acids, to study the driving forces for nucleic acid structure formation and to tune DNA and RNA hybridization conditions.
Engels, Joachim W. (Prof. Dr.) +1 more
core
Dynamics of a bubble formed in double stranded DNA
, 2008 We study the fluctuational dynamics of a tagged base-pair in double stranded DNA. We calculate the drift force which acts on the tagged base-pair using a potential model that describes interactions at base pairs level and use it to construct a Fokker ...
Kornberg A. Baker T. A. +5 more
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Sequence-specific double-strand cleavage of DNA by penta-N-methylpyrrolecarboxamide-EDTA·Fe(II) [PDF]
, 1983 In the presence of O2 and 5 mM dithiothreitol, penta-N-methylpyrrolecarboxamide-EDTA·Fe(II) [P5E·Fe(II)] at 0.5 µ M cleaves pBR322 plasmid DNA (50 µ M in base pairs) on opposite strands to afford discrete DNA fragments as analyzed by agarose gel ...
Dervan, Peter B., Schultz, Peter G.
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Self-organised criticality in base-pair breathing in DNA with a defect
, 2011 We analyse base-pair breathing in a DNA sequence of 12 base-pairs with a defective base at its centre. We use both all-atom molecular dynamics (MD) simulations and a system of stochastic differential equations (SDE).
Ambjörnsson +36 more
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Lattice Attacks on Pairing-Based Signatures [PDF]
Information Security Journal: A Global Perspective, 2017 Practical implementations of cryptosystems often suffer from critical information leakage through side-channels (such as their power consumption or their electromagnetic emanations). For public-key cryptography on embedded systems, the core operation is usually group exponentiation – or scalar multiplication on elliptic curves – which is a sequence of ...
Damien Vergnaud +2 more
openaire +3 more sources
A Mathematical Model for RNA 3D Structures
MathematicsThe computational prediction of RNA three-dimensional (3D) structures remains a significant challenge, largely due to the limited understanding of RNA folding pathways.
Sixiang Zhang, Liming Cai
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Aviram-Ratner rectifying mechanism for DNA base pair sequencing through graphene nanogaps
, 2012 We demonstrate that biological molecules such as Watson-Crick DNA base pairs can behave as biological Aviram-Ratner electrical rectifiers because of the spatial separation and weak hydrogen bonding between the nucleobases.
Christian Wolowiec +6 more
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Modeling DNA Structure, Elasticity and Deformations at the Base-pair Level
, 2003 We present a generic model for DNA at the base-pair level. We use a variant of the Gay-Berne potential to represent the stacking energy between neighboring base-pairs.
A. Sarkar +62 more
core +1 more source
Thermodynamics of base pairing
Current Opinion in Structural Biology, 1996 The study of the thermodynamics of base pairing is a rapidly expanding field due to its importance for taking advantage of opportunities presented by the growing database of nucleic acid sequences. Both natural and unnatural nucleic acids are being studied.
openaire +2 more sources