Results 61 to 70 of about 30,427,296 (288)
Journal of Nucleic Acids, 2010 Hydroxyl radicals are potent mutagens that attack DNA to form various base and ribose derivatives. One of the major damaged thymine derivatives is 5-formyluracil (fU), which induces pyrimidine transition during replication.
Masaru Tsunoda +7 more
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BASE PAIRING IN 5-CHLOROURIDINE
Proceedings of the National Academy of Sciences, 1969 5-Chlorouridine has been found to crystallize from water with the molecules of the nucleoside arranged in a base-paired, parallel-stranded ribbon. This type of polymer structure has not been previously considered for nucleic acids. We have constructed a model of polyuridylic acid based upon the 5-chlorouridine crystal structure and wish to suggest it ...
Stuart W. Hawkinson, Charles L. Coulter
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, 2016 We employ two Tight-Binding (TB) approaches to study the electronic structure and hole or electron transfer in B-DNA monomer polymers and dimer polymers made up of $N$ monomers (base pairs): (I) at the base-pair level, using the on-site energies of base ...
Chatzieleftheriou, M. +7 more
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Electron Attachment to Wobble Base Pairs
The Journal of Physical Chemistry A, 2023 We have analyzed the low-energy electron attachment to wobble base pairs using the equation motion coupled cluster method and extended basis sets. A doorway mechanism exists for the attachment of the additional electron to the base pairs, where the initially formed dipole-bound anion captures the incoming electron.
Jishnu Narayanan S J +3 more
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Base-pair Opening Dynamics of Nucleic Acids in Relation to Their Biological Function
Computational and Structural Biotechnology Journal, 2019 Base-pair opening is a conformational transition that is required for proper biological function of nucleic acids. Hydrogen exchange, observed by NMR spectroscopic experiments, is a widely used method to study the thermodynamics and kinetics of base-pair
Seo-Ree Choi +5 more
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Detection of genetic variation and base modifications at base-pair resolution on both DNA and RNA
Communications Biology, 2021 Wang et al. show how genetic sequence and base modifications can be detected simultaneously on single molecules of both DNA and RNA using magnetic tweezers.
Zhen Wang +16 more
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Twist versus Nonlinear Stacking in Short DNA Molecules
, 2014 The denaturation of the double helix is a template for fundamental biological functions such as replication and transcription involving the formation of local fluctuational openings.
Zoli, Marco
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Pd2+-mediated base pairing in oligonucleotides [PDF]
Journal of Inorganic Biochemistry, 2016 Two short glycol nucleic acid (GNA) oligonucleotides, having either a terminal or an intrachain nucleobase replaced by the pyridine-2,6-dicarboxamide chelate of Pd(2+), have been synthesized and their hybridization properties studied by melting temperature measurements.
Tuomas Lönnberg +3 more
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Base-pair ambiguity and the kinetics of RNA folding
BMC Bioinformatics, 2019 Background A folding RNA molecule encounters multiple opportunities to form non-native yet energetically favorable pairings of nucleotide sequences. Given this forbidding free-energy landscape, mechanisms have evolved that contribute to a directed and ...
Guangyao Zhou +2 more
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Computational and Structural Biotechnology Journal, 2021 The non-natural ethynylmethylpyridone C-nucleoside (W), a thymidine (T) analogue that can be incorporated in oligonucleotides by automated synthesis, has recently been reported to form a high fidelity base pair with adenosine (A) and to be well ...
Mohit Chawla +4 more
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