Results 71 to 80 of about 20,204 (286)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Violência contra crianças na cidade de Ribeirão Preto, São Paulo, Brasil: a prevalência dos maus-tratos calculada com base em informações do setor educacional Violence against children in the city of Ribeirão Preto, São Paulo State, Brazil: child abuse prevalence estimated from school system data

Cadernos de Saúde Pública, 2009
Os números oficiais dos maus-tratos infantis não correspondem à realidade, pois muitos casos não são notificados. No presente estudo, buscou-se estimar a prevalência em crianças de 0 a 10 anos matriculadas em estabelecimentos educacionais da rede pública
Juliana Martins Faleiros, Alessandra da Silva Araújo Matias, Marina Rezende Bazon   +2 more
doaj   +1 more source

Can a fast thinker be a good thinker? The neural correlates of base-rate neglect measured using a two-response paradigm

, 2021
Oshin Vartanian, Timothy K. Lam, Elaine Maceda, Wim De Neys   +3 more
openalex   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

How effective is albedo modification (solar radiation management geoengineering) in preventing sea-level rise from the Greenland Ice Sheet?

Environmental Research Letters, 2015
Albedo modification (AM) is sometimes characterized as a potential means of avoiding climate threshold responses, including large-scale ice sheet mass loss. Previous work has investigated the effects of AM on total sea-level rise over the present century,
Patrick J Applegate, Klaus Keller
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Debiasing the Base Rate Neglect with Visual Presentation

, 2021
Seitz, Chiara
openalex   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Trends on the Artificial Fertilizer Market and in Fertilizers Use in Hungary

Apstract: Applied Studies in Agribusiness and Commerce, 2018
The fertilizer market in Hungary is rather concentrated, which has a strong influence on the price of the fertilizer. Our domestic fertilizer use is primarily determined by that of nitrogen. The use of phosphorus is also significant but the trends in the
Gergő Ács
doaj   +1 more source