Results 161 to 170 of about 2,900,820 (292)

Beyond sequence: A physics-informed machine learning framework for predicting DNA mutations. [PDF]

Comput Struct Biotechnol J
Suárez-Villagrán M, Mitsakos N, Miller JH.   +2 more
europepmc   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Large-scale screening of genes responsible for silique length and seed size in Brassica Napus via pooled CRISPR library. [PDF]

BMC Genomics
Zhao C, Xia J, Liang B, Lin S, Song Y, Hong D, Gu J.   +6 more
europepmc   +1 more source

c-fos sequence necessary for basal expression and induction by epidermal growth factor, 12-O-tetradecanoyl phorbol-13-acetate and the calcium ionophore.

, 1987
T M Fisch, Ron Prywes, R G Roeder
openalex   +1 more source

A novelβthalassemia gene with a single base mutation in the conserved polypyrimidine sequence at the 3′ end of IVS 2 [PDF]

, 1988
Chérif Beldjord, Claudine Lapouméroulie, Josee Pagnier, M. Benabadji, Rajagopal Krishnamoorthy, Dominique Labie, A Bank   +6 more
openalex   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Structural basis for sequence context-independent single-stranded DNA cytosine deamination by the bacterial toxin SsdA. [PDF]

Nat Commun
Yin L, Chen Y, Shi K, Barreto Duran E, Harris RS, Aihara H.   +5 more
europepmc   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Tailoring Cas12a functionality with a user-friendly and versatile crRNA variant toolbox. [PDF]

Nat Commun
Han J, Min Y, Hu L, Chen JJ, Zhang SX, Li XF, Cheng ZH, Liu DF, Yu HQ.   +8 more
europepmc   +1 more source

TraJ protein of plasmid RP4 binds to a 19-base pair invert sequence repetition within the transfer origin

, 1989
Günter Ziegelin, Jens P. Fürste, Erich Lanka   +2 more
openalex   +1 more source