Results 181 to 190 of about 905,353 (315)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Protein-nucleic acid language model-assisted design of precise and compact adenine base editor. [PDF]

Nat Commun
Ren J, Yao J, Cao Q, Li Y, Li Y, Zhang Z, Ge X, Wang S, Zhang Y, Wang X, Zhang X.   +10 more
europepmc   +1 more source

Phylogenetic Study of Several Parasitic Plant Species Based on The atp-1 Gene Sequence

Pratama Ardo Cahya, Nadaa Karuniasari, Agnia Fadillah Rahmadini, A. G. Ezra, Victor Alvianoes Guterez Hose, Turhadi Turhadi, Eko Suyanto, Fatchiyah Fatchiyah   +7 more
openalex   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Versatile genome editing using Type I-E CRISPR-Cas3 in rice. [PDF]

Plant Cell Physiol
Saika H, Hara N, Yasumoto S, Muranaka T, Yoshimi K, Mashimo T, Toki S.   +6 more
europepmc   +1 more source

The first high-density sequence characterized SNP-based linkage map of olive (Olea europaea L. subsp. europaea) developed using genotyping by sequencing

, 2016
Annalisa Marchese, Francesco Paolo Marra, Tiziano Caruso, Khethani Give Mhelembe, Francesca Costa, Silvia Fretto, Daniel James Sargent, Daniel James Sargent   +7 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

TRX-LOGOS - a graphical tool to demonstrate DNA information content dependent upon backbone dynamics in addition to base sequence. [PDF]

Source Code Biol Med, 2015
Fortin CH, Schulze KV, Babbitt GA.
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Activation of bacterial transcription by distortion of promoter base pairing. [PDF]

Nucleic Acids Res
Klimova KM, Forrest D, Sharma P, Haycocks JRJ, Grainger DC.   +4 more
europepmc   +1 more source