Results 101 to 110 of about 8,322,522 (296)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Metodologia de avaliação de grau de degradação e rejuvenescimento de superligas à base de níquel [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Ciência e Engenharia de Materiais, Florianópolis, 2014.A microestrutura de superligas à base de níquel é constituída de grande quantidade de ...
Turazi, Almir
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Fort Eustis, VA, Joint Base Langley-Eustis: Restricted areas

, 2019
VI/A A A! 37°10'36" N 76°36'1" W37°10'33" N 76°36'20" W !A µ 37°10'29" N!A76°36'6" W 37°10'27" N76°35'45" W Fort Eustis, VA !A37°10'24" N ! 37°10'24" N76°36'2" W A 76°35'32" W 37°10'19"!N !A Joint Base Langley-Eustis A 76°36'7" W 37°10'13" N !A76°36'42 ...
Joint Base Langley-Eustis (Va.)
core  

Temperature Zoning, a Guide to Crop Management in Isfahan Province [PDF]

بوم شناسی کشاورزی
IntroductionThis temperature varies for each species, but there is a linear relationship between growing degree-days and plant growth rate. Growing degree-days (GDD) are used to classify plants by their flowering date, to estimate harvest maturity, and ...
AmirHooshang Jalali, Alireza Nikooei
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Factors Influencing the Variation of Plants’ Cardinal Temperature: A Case Study in Iran

Plants
The establishment and spread of plants in their native or alien geographical ranges are determined by their germination. This study investigated the impact of different factors on variations in cardinal temperatures. We used the lm procedure and measured
Sima Sohrabi, Javid Gherekhloo, Saeid Hassanpour-bourkheili, Afshin Soltani, Jose L. Gonzalez-Andujar   +4 more
doaj   +1 more source

Temperature and humidity control system in a lunar base

Advances in Space Research, 1992
An increasing number of lunar base construction programs are in the process of developing lunar resources such as helium 3. The objective of the present work is to evaluate the temperature and humidity control system, which will allow man to live and work on the moon while developing lunar resources.
Izutani, N., Kobayashi, N., Ogura, T., Nomura, I., Kawazoe, M., Yamamoto, H.   +5 more
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source