Results 111 to 120 of about 8,322,522 (296)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
On the 7-azaindole in acetonitrile anhydrous solutions as an inappropriate photophysical model for DNA base pairs [PDF]
, 2009 Multiple Hydrogen-bonding is a fundamental issue to explain base-pairing in DNA structures, which was firstly described by Watson and Crick^1^ using stable keto tautomer forms.
Javier Catalán
core
Phenological Development of Waxy-Leaved Mustard (Boreava orientalis Jaub. and Spach.)
PlantsWaxy-leaved mustard (Boreava orientalis Jaub. and Spach.) is an invasive weed that has rapidly spread across wheat fields in the Kurdistan Province, Iran. The germination and phenology of this species were studied through a series of greenhouse and field
Taiebeh Adeli +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Revista Facultad Nacional de Agronomía Medellín, 2012 Resumen. La temperatura tiene gran influencia sobre los cultivos y es clave en la determinación de la fecha de siembra, cosecha y las variables de producción.
Dubián Hoyos García +5 more
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Populations of arable weed species show intra-specific variability in germination base temperature but not in early growth rate. [PDF]
PLoS One, 2020 Bürger J, Malyshev AV, Colbach N.
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source