Results 41 to 50 of about 87,135 (264)
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Topological properties in ontology-based applications [PDF]
2011 11th International Conference on Intelligent Systems Design and Applications, 2011 Representation and reasoning with spatial properties is essential in several application domains where ontologies are being successfully applied; e.g., Information Fusion systems. This requires a full characterization of the semantics of relations such as adjacent, included, overlapping, etc.
Miguel A. Serrano +4 more
openaire +2 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Omnidirectional Vision Based Topological Navigation [PDF]
International Journal of Computer Vision, 2007 In this work we present a novel system for autonomous mobile robot navigation. With only an omnidirectional camera as sensor, this system is able to build automatically and robustly accurate topologically organised environment maps of a complex, natural environment.
Goedemé, Toon +3 more
openaire +3 more sources
Evaluation model for topology partition base on simulation run time
Tongxin xuebao, 2013 Firstly,by analyzing the PDES mechanism,a variety of factors affecting simulation performance were summa-rized and classified,and the factor set influenced by topology partition result was found out; and then,by analyzing simulation run time,an ...
Wen-tang GE, Zhao-xin ZHANG, Bin LI
doaj +2 more sources
Orderability and continuous selections for Wijsman and Vietoris hyperspaces
Applied General Topology, 2003 Bertacchi and Costantini obtained some conditions equivalent to the existence of continuous selections for the Wijsman hyperspace of ultrametric Polish spaces. We introduce a new class of hypertopologies, the macro-topologies.
Debora Di Caprio, Stephen Watson
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Argument-based Belief in Topological Structures [PDF]
Electronic Proceedings in Theoretical Computer Science, 2017 In Proceedings TARK 2017, arXiv:1707 ...
Chenwei Shi +2 more
openaire +5 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source