Results 51 to 60 of about 4,238,003 (295)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Topological properties in ontology-based applications [PDF]
2011 11th International Conference on Intelligent Systems Design and Applications, 2011 Representation and reasoning with spatial properties is essential in several application domains where ontologies are being successfully applied; e.g., Information Fusion systems. This requires a full characterization of the semantics of relations such as adjacent, included, overlapping, etc.
Miguel A. Serrano +4 more
openaire +2 more sources
Topology optimisation: increasing the speed and reliability of design [PDF]
, 2014 In this paper, topology optimisation is applied to the design of the rear fuselage of an unmanned aerial vehicle (UAV). A comparison is drawn between the performance of a design created through evolutionary structural optimisation (ESO) and a baseline ...
Andy Keane +7 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Topology Based Object Tracking [PDF]
Mathematical and Computational Applications, 2019 A model for tracking objects whose topological properties change over time is proposed. Such changes include the splitting of an object into multiple objects or the merging of multiple objects into a single object. The proposed model employs a novel formulation of the tracking problem in terms of homology theory whereby 0-dimensional homology classes ...
openaire +3 more sources
3-D topology optimization of single-pole-type head by using design sensitivity analysis [PDF]
, 2006 It is necessary to develop a write head having a large recording field and small stray field in adjacent tracks and adjacent bits in perpendicular magnetic recording systems.
Takahashi, Norio +2 more
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
2015 IEEE International Conference on Communications (ICC), 2015 Many data center network topologies are designed to provide full bisection bandwidth for tens of thousands of servers in order to achieve high network throughput and server agility. However, the utilization rate of DCNs on average is below 10%, which results in a significant waste of network resources and energy.
Yi, Qing, Singh, Suresh
openaire +3 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Omnidirectional Vision Based Topological Navigation [PDF]
International Journal of Computer Vision, 2007 In this work we present a novel system for autonomous mobile robot navigation. With only an omnidirectional camera as sensor, this system is able to build automatically and robustly accurate topologically organised environment maps of a complex, natural environment.
Goedemé, Toon +3 more
openaire +4 more sources