Results 51 to 60 of about 444,519 (336)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Topology Adaption for the Quantum Internet
, 2018 In the quantum repeater networks of the quantum Internet, the varying stability of entangled quantum links makes dynamic topology adaption an emerging issue. Here we define an efficient topology adaption method for quantum repeater networks.
Gyongyosi, Laszlo, Imre, Sandor
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Evaluation model for topology partition base on simulation run time
Tongxin xuebao, 2013 Firstly,by analyzing the PDES mechanism,a variety of factors affecting simulation performance were summa-rized and classified,and the factor set influenced by topology partition result was found out; and then,by analyzing simulation run time,an ...
Wen-tang GE, Zhao-xin ZHANG, Bin LI
doaj +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Entropy, 2022 Effective fault-diagnosis strategies have been the focus of research on multi-agent systems (MASs). In this paper, the belief rule base (BRB)-based distributed fault-diagnosis problem for MASs is investigated, and a topology-switching strategy is ...
Ziyi Wang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Topology-based stereochemistry representation [PDF]
Comptes Rendus de l'Académie des Sciences - Series IIC - Chemistry, 1998 We propose to use combinarorial maps as a non-geometric computer representation of convex polyhedral and polygonal stereogenic entities. 'This model is simple, uniform, and general. It allows to represent any relative spatial arrangement of atoms (stereogenic entities, molecular shapes, etc.).
Dietz, Andreas +3 more
openaire +2 more sources
Free and nearly free curves from conic pencils
, 2017 We construct some infinite series of free and nearly free curves using pencils of conics with a base locus of cardinality at most two. These curves have an interesting topology, e.g. a high degree Alexander polynomial that can be explicitly determined, a
Dimca, Alexandru
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