Results 41 to 50 of about 890,269 (304)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Did Bank Capital Regulation Exacerbate the Subprime Mortgage Crisis?
Discrete Dynamics in Nature and Society, 2009 This contribution is the second in a series of papers on discrete-time modeling of bank capital regulation and its connection with the subprime mortgage crisis (SMC). The latter was caused by, amongst other things, the downturn in the U.S. housing market,
M. A. Petersen +4 more
doaj +1 more source
Basel III countercyclical capital rules: implications for South Africa
South African Journal of Economic and Management Sciences, 2012 The financial crisis has been blamed on many entities, institutions and individuals as well as the Basel II accord which had just begun to be implemented globally when the crisis erupted. The criticisms resulted in the construction of Basel III, a series
Gary Wayne van Vuuren
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The effect of stressed economic conditions on credit risk in Basel II
South African Journal of Economic and Management Sciences, 2011 The robustness of the Basel II accord in protecting banks during volatile economic periods has been challenged in the ongoing credit crisis. In particular, advanced approaches to measuring and managing credit risk have drawn criticism for being both ...
Ja'nel Esterhuysen +2 more
doaj +1 more source
Mitigating the Pro-Cyclicality of Basel II [PDF]
SSRN Electronic Journal, 2010 This paper compares alternative procedures to mitigate the procyclicality of the new risk-sensitive bank capital regulation (Basel II). We estimate a model of the probabilities of default (PDs) of Spanish firms during the period 1987-2008, and use the estimated PDs to compute the corresponding series of Basel II capital requirements per unit of loans ...
Rafael Repullo +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
BASEL II DÜZENLEMESİ VE TÜRKİYE'YE ETKİLERİ
Selçuk Üniversitesi Sosyal Bilimler Meslek Yüksekokulu Dergisi, 2014 Basel Komitesi uluslararası finans piyasaları için yayınladığı BaselII düzenlemesini 2001 yılında yayınlayıp, tanıttı. Gelen yorum ve görüşlerden sonra en son hali 2004 yılında yayımlandı.
Baki Yılmaz, Mutlu Cerit
doaj
Risk management debate focused on banking industry
International Journal of Entrepreneurial Knowledge, 2013 Corporate governance is a subject of constant timeliness and broad interest, mainly aimed at ensuring adequate protection for investors and financial institutions.
Eugenia Ana Matis +2 more
doaj +1 more source