Results 41 to 50 of about 3,791,946 (289)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2016 Banking sector is considered as a backbone of any economy. It not only transacts money but also helps in promoting trade credit and various social welfare schemes of government. With the changing scenario of business, banking has also undergone a paradigm shift.
openaire +4 more sources
Transformation of the Ukrainian banking system regulation: a new horizon of compliance with the international framework [PDF]
Banks and Bank Systems, 2019 This article discusses the latest methodological recommendations of the Basel Committee on Banking Supervision developed in response to the effects of the global financial crisis and known as Basel III.
Lyubov Khudoliy, Oleg Bronin
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Towards a New Basel Accord with More Rigorous Settlements [PDF]
Theoretical and Applied Economics, 2010 The recent financial crisis made the banking sector more vulnerable to shocks. The system was characterised by weaknesses: too much leverage in the banking; not enough high quality capital to absorb losses and excessive credit growth based on ...
Petru PRUNEA, Daniela COSMA
doaj +1 more source
Selçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2016 KOBİ’ler için Uluslararası Finansal Raporlama Standartları KOBİ UFRS ve Basel III Kriterleri, KOBİ’leri yakından ilgilendiren iki önemli düzenlemedir.
Tuğrul Kandemir, Arif Arifoğlu
doaj
Jurnal ASET (Akuntansi Riset), 2019 Abastract. Legitimacy theory has a big role in strengthening the function of banks as intermediaries. This study aims to analyze bank compliance in lending in accordance with the provisions of the Basel Accord I - III. Based on the results of an analysis
Dadang Agus Suryanto
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source