Results 121 to 130 of about 350,934 (300)

Dissolved trace elements and nutrients in the North Sea—a current baseline

Environmental Monitoring and Assessment
AbstractPrimary production is an important driver of marine carbon storage. Besides the major nutrient elements nitrogen, phosphorus, and silicon, primary production also depends on the availability of nutrient-type metals (e.g., Cu, Fe, Mo) and the absence of toxicologically relevant metals (e.g., Ni, Pb).
Anna Siems, Tristan Zimmermann, Tina Sanders, Daniel Pröfrock   +3 more
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Scenarios as the basis for assessment of mitigation and adaptation [PDF]

, 2010
The possibilities and need for adaptation and mitigation depends on uncertain future developments with respect to socio-economic factors and the climate system. Scenarios are used to explore the impacts of different strategies under uncertainty.
Arnell, Nigel, Barker, T, Bauer, N, Berkhout, F, Criqui, P, Hilderink, H, Hinkel, J, Hof, A, Isaac, M., Kitous, A, Kram, T, Kundzewicz, Z., Mechler, R, Scrieciu, S, van Vuuren, D. P.   +14 more
core  

Salton Sea sampling program: baseline and toxicity studies [PDF]

, 1977
Baseline data on several of the Salton Sea fishes are reported. Morphometric (dimensions) and meristic (counting elements) data are presented as a baseline to evaluate any accumulation and physiological stresses that the fishes may experience as a result of geothermal development. Trace elements were analyzed in selected tissues or whole fish.
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Water Emissions Trading in Europe: A Literature Overview and Discussion of Opportunities [PDF]

, 2012
This report is about Water Emissions Trading (WET or Water Quality Trading) in Europe. The goal is to inform about the basic principles, provide an overview of studies done in Europe, and suggest some future opportunities for WET in ...
Michael H. A. Wind
core  

Baseline-Conditioned Spatial Heterogeneity in Ensemble-Learning Correction for Global Hourly Sea-Level Reconstruction

Journal of Marine Science and Engineering
This study examines how assessments of coastal extreme sea levels depend on the separability and reconstructability of the astronomical tide in hourly sea-level records.
Yu Hao, Yixuan Tang, Wen Du, Yang Li, Min Xu   +4 more
doaj   +1 more source

Accessing offshore wind turbines for maintenance : calculating access probabilities, expected delays and the associated costs using a probabilistic approach [PDF]

, 2012
There are ambitious plans in place for the expansion of offshore wind-power capacity in the EU and elsewhere. However, the cost of energy from offshore wind is much higher than that from land-based generation and anything between 15% and 30% of this cost
Feuchtwang, Julian, Infield, David
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source