Results 201 to 210 of about 2,517,057 (344)

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Atypical Anti-Glomerular Basement Membrane Disease: A Case for the Occam's Razor? [PDF]

Kidney Int Rep
Ivković V, Kronbichler A.
europepmc   +1 more source

Atypical Anti-Glomerular Basement Membrane Disease. [PDF]

Kidney Int Rep
Fernández-Lorente L, Shabaka A, Mora-Gutiérrez JM, Caravaca-Fontán F, Maldonado-Martín M, Cabello V, Marco H, Temprado A, Rivera C, Facal L, Barros X, González CC, Manrique J, Santos ÁP, Fernández-Juárez G.   +14 more
europepmc   +1 more source

Collagen IV diseases: A focus on the glomerular basement membrane in Alport syndrome.

Matrix Biology, 2017
D. Cosgrove, Shiguang Liu
semanticscholar   +1 more source

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source

Outcomes in Children and Adults With Antiglomerular Basement Membrane Disease. [PDF]

Kidney Int Rep
Suhlrie A, van der Meijden WAG, Faguer S, Alberici F, Idrizi A, Audard V, Servais A, Boyer O, Dossier C, Radermacher J, Skalioti C, Zieg J, Aksenova M, Raes A, Renson T, Mastrangelo A, Dorresteijn E, Terzi A, Bouts A, Teixeira AF, Herrero-Goñi M, Haffner D, Kanzelmeyer N.   +22 more
europepmc   +1 more source

Xstainer: A Novel Virtual Staining Tool Powered by Advanced Deep Learning Techniques

Advanced Intelligent Systems, EarlyView.
Xstainer is a deep learning–based virtual staining framework that converts hematoxylin and eosin‐stained whole slide images into multiple histochemical stains, including Masson's trichrome, Periodic acid‐Schiff, Jones methenamine silver, and Toluidine blue.
Fatma Nur Kinali, Derya Demir, Kutsev B. Ozyoruk, Yasin Almalioglu, Emre C. Kose, Drew F. K. Williamson, Gurdeniz Serin, G. Evren Keles, Banu S. Kumbaraci, Ceren Utku, Uguray P. Hacisalihoglu, Ilknur Turkmen, Figen Ozturk, Kayhan Basak, Yavuz Nuri Ertas, Mehmet Turan   +15 more
wiley   +1 more source

Diabetes mellitus with anti-glomerular basement membrane disease and anti-tubular basement membrane disease: a rare case report of reversible dialysis dependence. [PDF]

Front Immunol
Hu J, Liang Y, Sun K, Xiao Y.
europepmc   +1 more source

Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood–brain barrier

Journal of Neurochemistry, 2017
M. S. Thomsen, S. Birkelund, A. Burkhart, A. Stensballe, T. Moos   +4 more
semanticscholar   +1 more source

Lung maneuvers of large amplitudes for probing physiological alterations in mouse models of asthma

Animal Models and Experimental Medicine, EarlyView.
Lung maneuvers of small amplitudes, such as the ones performed in oscillometry, are the current gold standard to probe lung mechanics in animals, but they are insensitive to detect baseline physiological alterations in mouse models of asthma. Herein, lung maneuvers of different amplitudes were compared in two mouse models of asthma.
Magali Boucher, Cyndi Henry, Marie‐Josée Beaulieu, Andrés Rojas‐Ruiz, Ynuk Bossé   +4 more
wiley   +1 more source