Results 171 to 180 of about 7,695,341 (360)

Correction: Cell-free mitochondrial DNA as a potential predictor for hypoxic stress. [PDF]

open access: yesMol Biol Rep
Qu Q   +8 more
europepmc   +1 more source

Marketization of the basic school

open access: yes, 2011
Marketization of the basic school The report investigates the consequences of the increasing use of New Public Management initiatives in the basic schools in Copenhagen based on interviews from five schools.
Gren, Signe   +4 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Dual-chirality flexagon linkages with infinite eversion and surface reconfigurability. [PDF]

open access: yesProc Natl Acad Sci U S A
Lin J   +6 more
europepmc   +1 more source

DNA Methylation and Its Basic Function

open access: yesNeuropsychopharmacology, 2013
Lisa D. Moore, Thuc M. Le, G. Fan
semanticscholar   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

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