Results 41 to 50 of about 2,706,012 (265)

From Kyoto Protocol to Paris Agreement: An Analysis of Global Climate Regime Changes Based on a Study of the Evolution of Green Gases Emissions Profiles

Desenvolvimento e Meio Ambiente, 2017
This paper uses the notion of climate regime provided by the International Relations literature and by interdisciplinary approaches on climate change.
Maria Cristina Oliveira Souza, Rosana Icassatti Corazza   +1 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

INTENSIDAD DE LOS SABORES BÁSICOS DEL TOMATE (Lycopersicon esculentum) EN SEIS ESTADOS DE MADUREZ INTENSITY OF BASIC TASTES OF TOMATO (Lycopersicon esculentum) IN SIX MATURITY STAGES

Biotecnología en el Sector Agropecuario y Agroindustrial, 2009
El tomate (Lycopersicon esculentum), la hortaliza más sembrada en Colombia, es considerada una de las más importantes por su volumen de producción y demanda.
KATHERIN CASTRO, MARÍA LORENA RESTREPO, GONZALO TABORDA, GENY ASTRID QUINTERO   +3 more
doaj  

A Cross-sectional Analysis of Conventional Leishman’s Stain versus Modified Leishman’s Stain: A Study Protocol [PDF]

Journal of Clinical and Diagnostic Research
Introduction: The conventional Leishman’s stain and modified Leishman’s stain are widely used in medical laboratories for the microscopic examination of blood smears.
Isha Nanaji Panbude, Sahitya Vodithala
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Cultura organizacional desde la teoría de Edgar Schein: Estudio fenomenológico

CLIO América, 2015
The article presents the study of a phenomenon of corporate life from the description of the organizational culture in three organizations of educational character in Santa Marta-Colombia, whose objective was guided to describe the organizational ...
Lilibeth Pedraza-Álvarez, Kelly Obispo-Salazar, Lina Vásquez-González, Leonardo Gómez-Gómez   +3 more
doaj  

Missing the Forest for the Trees

Canadian Journal of Bioethics
This response expands on Wyzynski’s focus of the importance of fostering elementary ethics deliberation and education within hospitals. In particular, it highlights that most of the clinical ethicist’s work revolves around basic, fundamental ethical ...
Jordan Potter
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source