Results 81 to 90 of about 2,951,238 (252)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Determining karyotype of sturgeons
Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 1995 Karyotype of sturgeons Huso huso, Acipenser stellatus, and Acipenser persicus from southern region of- the Caspian Sea, has been examined by use of blood tissue culture. By counting fifty completely extended metaphase plates, the number of chromosomes in
M. Norozfashkhami; M. Khosroshahi
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Research progress of platelet function in immune regulation: from basic to clinical
Zhongguo shuxue zazhiTraditionally, platelets, which are anucleate cell fragments derived from blood cells, have been primarily associated with their pivotal functions in hemostasis and thrombosis.
HUANG Weihua +8 more
doaj +1 more source
Having material basics is basic
Medical Journal of Australia, 2023 Sharon R, Goldfeld +2 more
openaire +2 more sources
Declaração conjunta da XII Reunião ministerial do BASIC sobre mudança do clima : Brasília, Brasil, 20 e 21 de setembro, 2012 [PDF]
, 2014 Los representantes de los países miembros del Grupo BASIC se reúnen para tratar el tema del cambio climático y el desarrollo sustentable, entre otras cuestiones.Instituto de Relaciones Internacionales ...
Grupo BASIC
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Separating the basic logics of the basic recurrences
Annals of Pure and Applied Logic, 2012 This paper shows that, even at the most basic level, the parallel, countable branching and uncountable branching recurrences of Computability Logic (see http://www.cis.upenn.edu/~giorgi/cl.html) validate different principles.
openaire +3 more sources