Results 101 to 110 of about 3,095,661 (250)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Inequity in access to palliative care services worldwide and in Slovenia

Radiology and Oncology
Palliative care aims to enhance the quality of life of patients and their families facing progressive and incurable disease by addressing physical, psychological, social, and spiritual challenges.
Golob Nena, Moltara Maja Ebert
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

DIAGNOSTICS OF LEVELS OF FUTURE PRIMARY SCHOOL TEACHERS’ INFORMATIVE COMPETENCE

Ìнформаційні технології в освіті, 2013
The article describes the main structural components of future primary school teachers’ informative competence according to modern researches, diagnostic methods and results of future primary school teachers’ informative competence levels are ...
V. Kotkova
doaj  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Adult Basic Education Guidance and Counseling Workshop, June 22-26, 1970 [PDF]

, 1970
Final report on the Adult Basic Education Guidance and Counseling Workshop conducted from June 22 to June 26, 1970 and submitted by Appalachian Adult Basic Education Demonstration Center at Morehead State ...
Appalachian Adult Basic Education Demonstration Center
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Certificate of Proficiency in the Basic Sciences (1958-09-15)

, 1958
Certificate of proficiency in the basic sciences issued to Fred Simon Preuss. Issued by the State of Texas Board of Examiners in the Basic Sciences. Signed by president and secretary Brother Raphael Wilson.
Texas Board of Examiners in the Basic Sciences
core   +1 more source

Improved resource-saving technology of soil cultivation and use of bio-preparations for spring cereals crops under conditions of central zone of North-East of European part of Russia

Аграрная наука Евро-Северо-Востока, 2017
Results of 2013-2015 three-factor experiments on study of ways of basic, pre-sowing soil cultivation and use of bio-preparations were presented in the article; their influence on productivity of plant species of crops rotation chain was showed ...
L. M. Kozlova, F. A. Popov, E. N. Noskova, V. L. Ivanov   +3 more
doaj